{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:25:54Z","timestamp":1790007954326,"version":"4.0.1"},"reference-count":58,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>We aimed to determine whether cognitively unimpaired (CU) amyloid\u2010 beta\u2010positive (A\u03b2+) individuals display decreased practice effects on serial neuropsychological testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We included 209 CU participants from three research centers, 157 A\u03b2\u2212 controls and 52 A\u03b2+ individuals. Participants underwent neuropsychological assessment at baseline and annually during a 2\u2010year follow\u2010up. We used linear mixed\u2010effects models to analyze cognitive change over time between the two groups, including time from baseline, amyloid status, their interaction, age, sex, and years of education as fixed effects and the intercept and time as random effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      The A\u03b2+ group showed reduced practice effects in verbal learning (\u03b2\u00a0=\u00a0\u22121.14, SE\u00a0=\u00a00.40,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.0046) and memory function (\u03b2\u00a0=\u00a0\u22120.56, SE\u00a0=\u00a00.19,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.0035), as well as in language tasks (\u03b2\u00a0=\u00a0\u22120.59, SE\u00a0=\u00a00.19,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.0027).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Individuals with normal cognition who are in the Alzheimer's continuum show decreased practice effects over annual neuropsychological testing. Our findings could have implications for the design and interpretation of primary prevention trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>This was a multicenter study on practice effects in asymptomatic A\u03b2+ individuals.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>We used LME models to analyze cognitive trajectories across multiple domains.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Practice\u2010effects reductions might be an indicator of subtle cognitive decline.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Implications on clinical and research settings within the AD field are discussed.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70016","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T02:04:01Z","timestamp":1743127441000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Decreased practice effects in cognitively unimpaired amyloid betapositive individuals: a multicenter, longitudinal, cohort study"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5646-0482","authenticated-orcid":false,"given":"Adri\u00e0","family":"Tort\u2010Merino","sequence":"first","affiliation":[{"name":"Alzheimer's Disease and Other Cognitive Disorders Unit, Hospital Cl\u00ednic de Barcelona. Fundaci\u00f3 de Recerca Cl\u00ednic Barcelona \u2013 Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) University of Barcelona Barcelona Catalonia Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Neurodegenerativas (CIBERNED) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"P\u00e9rez\u2010Millan","sequence":"additional","affiliation":[{"name":"Alzheimer's Disease and Other Cognitive Disorders Unit, Hospital Cl\u00ednic de Barcelona. Fundaci\u00f3 de Recerca Cl\u00ednic Barcelona \u2013 Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) University of Barcelona Barcelona Catalonia Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Neurodegenerativas (CIBERNED) Madrid Spain"},{"name":"eHealth Center, Faculty of Computer Science Multimedia and Telecommunications, Universitat Oberta de Catalunya Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neus","family":"Falg\u00e0s","sequence":"additional","affiliation":[{"name":"Alzheimer's Disease and Other Cognitive Disorders Unit, Hospital Cl\u00ednic de Barcelona. 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