{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:09:08Z","timestamp":1791857348101,"version":"4.3.4"},"reference-count":122,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35GM138636"],"award-info":[{"award-number":["R35GM138636"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG068331"],"award-info":[{"award-number":["R01AG068331"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RF1AG082339"],"award-info":[{"award-number":["RF1AG082339"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30AG072946"],"award-info":[{"award-number":["P30AG072946"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG082730"],"award-info":[{"award-number":["R01AG082730"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006312","name":"BrightFocus Foundation","doi-asserted-by":"publisher","award":["A2020161S"],"award-info":[{"award-number":["A2020161S"]}],"id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["2019\u2010AARG44082"],"award-info":[{"award-number":["2019\u2010AARG44082"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001797","name":"Pharmaceutical Research and Manufacturers of America Foundation","doi-asserted-by":"publisher","award":["RSGTMT17"],"award-info":[{"award-number":["RSGTMT17"]}],"id":[{"id":"10.13039\/100001797","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005202","name":"Muscular Dystrophy Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005202","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      We systematically reviewed and meta\u2010analyzed bulk RNA sequencing (RNAseq) studies comparing Alzheimer's disease (AD) patients to controls in human brain tissue. We searched PubMed, Web of Science, and Scopus for human brain bulk RNAseq studies, excluding re\u2010analyses and studies limited to small RNAs or gene panels. We developed 10 criteria for quality assessment and performed a meta\u2010analysis on three high\u2010quality datasets. Of 3266 records, 24 qualified for the systematic review, and one study with three datasets qualified for the meta\u2010analysis. The meta\u2010analysis identified 571 differentially expressed genes (DEGs) in the temporal lobe and 189 in the frontal lobe, including\n                      <jats:italic>CLU<\/jats:italic>\n                      and\n                      <jats:italic>GFAP<\/jats:italic>\n                      . Pathway analysis suggested reactivation of developmental processes in the adult AD brain. Limited data availability constrained the meta\u2010analysis. These findings underscore the need for rigorous methods in AD transcriptomic research to better identify transcriptomic changes and advance biomarker and therapeutic development. This review is registered in PROSPERO (CRD42023466522).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>\n                            <jats:bold>Comprehensive review<\/jats:bold>\n                            : Conducted the first systematic review and meta\u2010analysis of bulk RNA sequencing (RNAseq) studies comparing Alzheimer's disease (AD) patients with non\u2010demented controls using primary human brain tissue.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            <jats:bold>Key findings<\/jats:bold>\n                            : Identified 571 differentially expressed genes (DEGs) in the temporal lobe and 189 in the frontal lobe of patients with AD, revealing potential therapeutic targets.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            <jats:bold>Pathway discovery<\/jats:bold>\n                            : Highlighted key overlapping pathways such as \u201ctube morphogenesis\u201d and \u201cneuroactive ligand\u2010receptor interaction\u201d that may play critical roles in AD.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            <jats:bold>Quality assessment<\/jats:bold>\n                            : Emphasized the importance of methodological rigor in transcriptomic studies, including quality assessment tools to guide future research in AD.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            <jats:bold>Study limitation<\/jats:bold>\n                            : Acknowledged limited access to complete data tables and lack of diversity in existing datasets, which constrained some of the analysis.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70025","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T22:48:49Z","timestamp":1741733329000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Systematic review and meta\u2010analysis of bulk RNAseq studies in human Alzheimer's disease brain tissue"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6177-9316","authenticated-orcid":false,"given":"Bernardo","family":"Aguzzoli Heberle","sequence":"first","affiliation":[{"name":"Sanders\u2010Brown Center on Aging University of Kentucky  Lexington Kentucky USA"},{"name":"Department of Neuroscience, College of Medicine University of Kentucky  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin L.","family":"Fox","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, College of Medicine University of Kentucky  Lexington Kentucky USA"},{"name":"Division of Laboratory Animal Resources University of Kentucky  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Lobraico Libermann","sequence":"additional","affiliation":[{"name":"School of Medicine Brain Institute of Rio Grande do Sul Pontifical Catholic University of Rio Grande do Sul (PUCRS)  Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Ronchetti Martins Xavier","sequence":"additional","affiliation":[{"name":"School of Medicine University of the Sinos Valley (UNISINOS)  S\u00e3o Leopoldo Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme","family":"Tarnowski Dallarosa","sequence":"additional","affiliation":[{"name":"School of Medicine Brain Institute of Rio Grande do Sul Pontifical Catholic University of Rio Grande do Sul (PUCRS)  Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhan\u00e1","family":"Carolina Santos","sequence":"additional","affiliation":[{"name":"School of Medicine University of the Sinos Valley (UNISINOS)  S\u00e3o Leopoldo Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Fardo","sequence":"additional","affiliation":[{"name":"Sanders\u2010Brown Center on Aging University of Kentucky  Lexington Kentucky USA"},{"name":"Department of Biostatistics University of Kentucky  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago","family":"Wendt Viola","sequence":"additional","affiliation":[{"name":"School of Medicine Brain Institute of Rio Grande do Sul Pontifical Catholic University of Rio Grande do Sul (PUCRS)  Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark T. W.","family":"Ebbert","sequence":"additional","affiliation":[{"name":"Sanders\u2010Brown Center on Aging University of Kentucky  Lexington Kentucky USA"},{"name":"Department of Neuroscience, College of Medicine University of Kentucky  Lexington Kentucky USA"},{"name":"Division of Biomedical Informatics, Internal Medicine, College of Medicine University of Kentucky  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,5]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"2023 Alzheimer's disease facts and figures.2023\u2010Alzheimer's & Dementia.Wiley Online Library. Accessed July 1 2024.https:\/\/alz\u2010journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.13016"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20102667(21)00249\u20108"},{"key":"e_1_2_11_4_1","unstructured":"Dementia. Accessed August 12 2024.https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/dementia"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12362"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.14506.1"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2022.01.016"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1997.01830150090013"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.2.168"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010022\u201001024\u2010z"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010024\u201001939\u20109"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896\u20106273(90)90100\u2010t"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896\u20106273(90)90169\u2010g"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2111579"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925\u20104439(00)00043\u20100"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.11.4051"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460\u20102075.1989.tb03390.x"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00158a027"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166\u20102236(91)90105\u20104"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471\u20104159.2007.04857.x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304\u20103940(00)01753\u20105"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2005.09.004"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2005.07.004"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2007.07.021"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2006.10.028"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23\u201009\u201003807.2003"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2006.08.014"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2011.06.007"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41576\u2010019\u20100150\u20102"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.03.023"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature22973"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat8127"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41514\u2010020\u201000052\u20105"},{"key":"e_1_2_11_34_1","unstructured":"AD Knowledge Portal. Accessed July 16 2024.https:\/\/adknowledgeportal.synapse.org\/"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/sdata.2016.89"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/sdata.2018.185"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/sdata.2018.142"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2024.3770"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059\u2010016\u20100881\u20108"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/sdata.2016.18"},{"key":"e_1_2_11_42_1","doi-asserted-by":"crossref","unstructured":"Marques\u2010CoelhoD et al.Differential Transcript Usage Unravels Gene Expression Alterations in Alzheimer\u2019s Disease Human Brains. (2020) 2020.03.19.20038703 Preprint at doi:10.1101\/2020.03.19.20038703","DOI":"10.1101\/2020.03.19.20038703"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq340"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201009234\u20106"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0177459"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010018\u20100238\u20101"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010021\u201001266\u2010z"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbih.2021.100227"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202300876"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.31126"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016266"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2012.12.042"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010021\u201002356\u20103"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13326"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2018.10.023"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.2217\/epi\u20102022\u20100096"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2019.06.004"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010150398"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13153"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12894"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010141989"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201083872\u2010z"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.3233\/ADR220114"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201022701\u20102"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13387"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2022.105938"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201065916\u2010y"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13041\u2010022\u201000963\u20102"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2017.06.008"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.15398.3"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587\u2010024\u201002245\u20109"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592\u2010023\u201002026\u20103"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592\u2010024\u201002298\u20103"},{"key":"e_1_2_11_74_1","doi-asserted-by":"crossref","unstructured":"ChenY DavidsonNM WanYK et\u00a0al.A systematic benchmark of Nanopore long read RNA sequencing for transcript level analysis in human cell lines. Published online April 22 2021:2021.04.21.440736. doi:10.1101\/2021.04.21.440736","DOI":"10.1101\/2021.04.21.440736"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.12"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197\u20102456(86)90046\u20102"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2006.10.012"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1711357114"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024\u2010023\u201000611\u2010w"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22115864"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2000.4139"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr077"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)77753-9"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)50929-2"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/4048527"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1177\/15330338221078728"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/1873\u20103468.13057"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2022.09.010"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2999"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M302042200"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201023111\u20101"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.06.005"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201042819\u2010w"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10038\u2010004\u20100162\u20103"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx370"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0562\u201023.2023"},{"key":"e_1_2_11_97_1","doi-asserted-by":"crossref","unstructured":"MittelstaedtT Alvar\u00e9z\u2010BaronE SchochS.RIM proteins and their role in synapse function.2010;391(6):599\u2010606. doi:10.1515\/bc.2010.064","DOI":"10.1515\/bc.2010.064"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010017\u20100049\u20107"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awae035"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2014.01.055"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12091309"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012109"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010022\u201001716\u20102"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000209537"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.3671"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1032192"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcab261"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0531\u20105565(96)00159\u20103"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2023.3599"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.05.018"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.08.039"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201007606\u20107"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2022.03.008"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010019\u20101195\u20102"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010019\u20100695\u20109"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010019\u20100539\u20104"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478\u2010022\u201001494\u20106"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2016.132"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1080\/15476286.2021.1978215"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2023.04.006"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2022.10.023"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2023.11.002"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25063098"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.70025","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.70025","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.70025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T10:21:21Z","timestamp":1789554081000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.70025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":122,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/alz.70025"],"URL":"https:\/\/doi.org\/10.1002\/alz.70025","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"2024-10-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70025"}}