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Applying a two\u2010cutoff approach improved the specificity without reducing sensitivity. The p\u2010tau217\/A\u03b242 ratio had a lower intermediate percentage than p\u2010tau217 alone in both clinic (10.6% vs 13.0%) and community (16.5% vs 31.4%) cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Plasma p\u2010tau217\/A\u03b242 has high performance in detecting cerebral AD pathologies, thus offering a promising tool for clinical diagnosis and community screening of AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Lumipulse G plasma p\u2010tau217 and the p\u2010tau217\/A\u03b242 ratio accurately identified abnormal A\u03b2 and tau PET statuses in both clinical and community cohorts.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The performance of plasma p\u2010tau217 and p\u2010tau217\/A\u03b242 ratio were equivalent to CSF tests.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Plasma p\u2010tau217\/A\u03b242 ratio outperformed p\u2010tau217 alone in identifying A\u03b2 PET positivity, and this superiority is more obvious in the community cohort, suggesting an advantage in the early diagnosis of AD.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Two cut points of p\u2010tau217\/A\u03b242 were established in the Chinese population for clinical laboratory and community screening uses.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  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