{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:03:36Z","timestamp":1789556616747,"version":"build-2803163510"},"reference-count":65,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F31AG087696\u201001"],"award-info":[{"award-number":["F31AG087696\u201001"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5T32NS115704\u201002"],"award-info":[{"award-number":["5T32NS115704\u201002"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U19AG078109"],"award-info":[{"award-number":["U19AG078109"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>High levels of chronic stress and low social support have been associated with worse cognition among older adults, but the underlying mechanisms remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We included 2117 older adults (mean age 65.5 years) enrolled in the Health and Aging Brain Study \u2013 Health Disparities (HABS\u2010HD). Linear regression models evaluated the associations between social support or chronic stress and Alzheimer's\u2010related blood\u2010based biomarkers (BBMs), including amyloid beta (A\u03b2) 42\/40 ratio, neurofilament light chain (NfL), phosphorylated tau (p\u2010tau)181, and total tau (t\u2010tau). Interactions between chronic stress or social support and gender or race\/ethnicity in relation to BBMs were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Higher chronic stress was associated with higher levels of t\u2010tau. Higher social support was associated with lower levels of NfL. Neither gender nor race\/ethnicity modified the associations between chronic stress or social support and BBM levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Chronic stress and social support are associated with BBMs of neurodegeneration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Higher chronic stress was associated with higher levels of plasma total tau.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Higher social support was associated with lower levels of plasma neurofilament light chain.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Neither gender nor race\/ethnicity modified the associations between chronic stress or social support and levels of blood\u2010based biomarkers.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Chronic stress and social support affect pathways related to neurodegeneration.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70043","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T22:34:27Z","timestamp":1741732467000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Chronic stress, social support, and Alzheimer's blood\u2010based biomarkers in the HABS\u2010HD study"],"prefix":"10.1002","volume":"21","author":[{"given":"Jillian K.","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Prevention Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leigh","family":"Johnson","sequence":"additional","affiliation":[{"name":"Institute for Translational Research University of North Texas Health Science Center  Fort Worth USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Hall","sequence":"additional","affiliation":[{"name":"Institute for Translational Research University of North Texas Health Science Center  Fort Worth USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Bateman","sequence":"additional","affiliation":[{"name":"Department of Neurology Wake Forest Baptist Medical Center  Winston\u2010Salem North Carolina 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