{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:04:35Z","timestamp":1789556675700,"version":"build-2803163510"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T00:00:00Z","timestamp":1742428800000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG053184"],"award-info":[{"award-number":["R01AG053184"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG067021"],"award-info":[{"award-number":["R01AG067021"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG058825\u201001A"],"award-info":[{"award-number":["R01AG058825\u201001A"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P01AG036694"],"award-info":[{"award-number":["P01AG036694"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Accelerated long\u2010term forgetting (LTF) might be an early marker of subtle memory changes in older adults at risk for Alzheimer's disease (AD). We leveraged remote, multi\u2010day digital testing to characterize LTF in older adults and investigated its association with initial learning and AD imaging biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>One hundred four cognitively unimpaired older adults completed a face\u2013name memory task for seven consecutive days and were asked to recognize face\u2013name pairs 1 week later. LTF was computed as the number of correctly identified stimuli divided by a participant's maximum performance during learning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Better learning was associated with less LTF (\u03b2\u00a0=\u00a00.52, 95% confidence interval [CI]:0.34\u20130.71,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Accelerated LTF was associated with cortical thinning in AD\u2010signature regions (\u03b2\u00a0=\u00a00.33, 95% CI: 0.13\u20130.52,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.001), but associations with regional tau were more subtle.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Remote, multi\u2010day testing may facilitate the assessment of LTF as an early cognitive marker of preclinical AD, but further replication is needed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Using digital, remote assessments, we evaluated long\u2010term forgetting in cognitively unimpaired older adults.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>We found a potential association between long\u2010term forgetting and tau in Alzheimer's disease (AD)\u2013related regions.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Assessing long\u2010term forgetting may facilitate early detection of AD\u2010related cognitive decline.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70047","type":"journal-article","created":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T07:40:32Z","timestamp":1742456432000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Using remote, digital, multi\u2010day testing to characterize long\u2010term forgetting in cognitively unimpaired older adults"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4969-7661","authenticated-orcid":false,"given":"Cassidy P.","family":"Molinare","sequence":"first","affiliation":[{"name":"Department of Neurology Brigham and Women's Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Soberanes","sequence":"additional","affiliation":[{"name":"Department of Neurology Brigham and Women's Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Dubbelman","sequence":"additional","affiliation":[{"name":"Department of Neurology Brigham and Women's Hospital, Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Neurology Massachusetts General Hospital, Harvard Medical School  Boston Massachusetts 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