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This study tested whether marital status was associated with dementia risk in older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Participants (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a024,107; Mean\n                      <jats:sub>age\u00a0<\/jats:sub>\n                      =\u00a071.79) were from the National Alzheimer's Coordinating Center. Cox regressions tested the association between baseline marital status and clinically ascertained dementia over up to 18 years of follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Compared to married participants, widowed (hazard ratio [HR]\u00a0=\u00a00.73, 95% confidence interval [95% CI]\u00a0=\u00a00.67\u20130.79), divorced (HR\u00a0=\u00a00.66, 95% CI\u00a0=\u00a00.59\u20130.73), and never\u2010married participants (HR\u00a0=\u00a00.60, 95% CI\u00a0=\u00a00.52\u20130.71) were at lower dementia risk, including for Alzheimer's disease and Lewy body dementia. The associations for divorced and never married remained significant accounting for demographic, behavioral, clinical, genetic, referral source, participation, and diagnostic factors. The associations were slightly stronger among professional referrals, males, and relatively younger participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Unmarried individuals may have a lower risk of dementia compared to married adults. The findings could indicate delayed diagnoses among unmarried individuals or challenge the assumption that marriage protects against dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Widowed, divorced, and never\u2010married older adults had a lower dementia risk, compared to their married counterparts.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Unmarried older adults were also at a lower risk of Alzheimer's disease and Lewy body dementia, with a pattern of mixed findings for frontotemporal lobar degeneration, and no associations with risk of vascular dementia or mild cognitive impairment.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>All unmarried groups were at a lower risk of progression from mild cognitive impairment to dementia.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>There was some evidence of moderation by age, sex, and referral source. However, stratified analyses showed small differences between groups, and most interactions were not significant, suggesting that the role of marital status in dementia tends to be similar across individuals at different levels of dementia risk due to education, depression, and genetic vulnerability.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70072","type":"journal-article","created":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T07:54:44Z","timestamp":1742457284000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Marital status and risk of dementia over 18 years: Surprising findings from the National Alzheimer's Coordinating Center"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8629-4422","authenticated-orcid":false,"given":"Selin","family":"Karakose","sequence":"first","affiliation":[{"name":"Florida State University College of Medicine  Tallahassee Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Luchetti","sequence":"additional","affiliation":[{"name":"Florida State University College of Medicine  Tallahassee Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannick","family":"Stephan","sequence":"additional","affiliation":[{"name":"University of Montpellier Euromov UFRSTAPS  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelina R.","family":"Sutin","sequence":"additional","affiliation":[{"name":"Florida State University College of Medicine  Tallahassee Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Terracciano","sequence":"additional","affiliation":[{"name":"Florida State University College of Medicine  Tallahassee Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl\u20102018\u2010313005"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1047-2797(99)00052-6"},{"key":"e_1_2_8_4_1","volume-title":"The Case for Marriage: Why Married People are Happier, Healthier and Better off Financially","author":"Waite L","year":"2001"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2307\/2061670"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/gbz087"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102015\u2010008565"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877\u2010024\u201004975\u20106"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102017\u2010316274"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/wad.0000000000000020"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2019.08.007"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.53.9.1953"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0192513X19839735"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1037\/pspp0000270"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357\u2010024\u201001443\u20102"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10902\u2010022\u201000613\u20103"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/geroni\/igae033"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000366555"},{"key":"e_1_2_8_19_1","unstructured":"U.S. Census Bureau.Historical marital status tables.2024. 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