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We hypothesized MSNs could provide cortical patterns linked with neighborhood disadvantage and cognitive function, explaining the potential risk of cognitive impairment in disadvantaged neighborhoods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      For cognitively unimpaired participants from the Wisconsin Alzheimer's Disease Research Center or Wisconsin Registry for Alzheimer's Prevention (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0524), and the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0100), neighborhood disadvantage was obtained using Area Deprivation Index (ADI) and its association with cognitive performance and MSN features was analyzed using linear regression and mediation analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Neighborhood disadvantage was associated with worse cognitive performance on memory, executive function, processing speed, and preclinical Alzheimer's tests on both datasets. Local morphological organization of predominantly the frontal and temporal regions showed association trends with ADI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Morphological patterns associated with ADI, in\u2010part, may explain the risk for poor cognitive functioning in a neighborhood disadvantaged population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Social determinants of health such as neighborhood context can be studied using ADI.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>High neighborhood disadvantage was related to worse performance on category fluency, implicit learning speed, story recall memory and pre\u2010clinical Alzheimer's cognitive composite.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>In this exploratory study, using morphological brain networks that indicate similarity in distribution of cortical thickness between regions, we observed that centrality of predominantly frontal and temporal regions was marginally linked with neighborhood disadvantage status and also partially mediated its association with preclinical Alzheimer's composite test.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>There is a potential role for considering neighborhood status in early screening of cognitive impairment and dementia.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70095","type":"journal-article","created":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T08:08:26Z","timestamp":1742458106000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Association of neighborhood disadvantage with cognitive function and cortical disorganization in an unimpaired cohort: An exploratory study"],"prefix":"10.1002","volume":"21","author":[{"given":"Apoorva","family":"Safai","sequence":"first","affiliation":[{"name":"Department of Radiology School of Medicine and Public Health University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R","family":"Buckingham","sequence":"additional","affiliation":[{"name":"Center for Health Disparities Research University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin M","family":"Jonaitis","sequence":"additional","affiliation":[{"name":"Department of Medicine School of Medicine and Public Health University of Wisconsin\u2010Madison  Madison Wisconsin USA"},{"name":"Wisconsin Alzheimer's Institute School of Medicine and Public Health University of Wisconsin\u2010Madison  Madison Wisconsin USA"},{"name":"Wisconsin Alzheimer's Disease Research Center School of Medicine and Public Health University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca E","family":"Langhough","sequence":"additional","affiliation":[{"name":"Department of Medicine School of Medicine and Public Health University of Wisconsin\u2010Madison  Madison Wisconsin USA"},{"name":"Wisconsin Alzheimer's Institute School of Medicine and Public Health University of Wisconsin\u2010Madison  Madison Wisconsin USA"},{"name":"Wisconsin Alzheimer's Disease Research Center School of Medicine and Public Health University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sterling C.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Medicine School of Medicine and Public Health University of Wisconsin\u2010Madison  Madison Wisconsin USA"},{"name":"Wisconsin Alzheimer's Institute School of Medicine and Public Health University of Wisconsin\u2010Madison  Madison Wisconsin USA"},{"name":"Wisconsin Alzheimer's Disease Research Center School of Medicine and Public Health University of Wisconsin\u2010Madison  Madison Wisconsin USA"},{"name":"Division of Geriatrics and Gerontology Department of Medicine School of Medicine and Public Health University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Ryan","family":"Powell","sequence":"additional","affiliation":[{"name":"Center for Health Disparities Research University of Wisconsin\u2010Madison  Madison Wisconsin USA"},{"name":"Division of Geriatrics and Gerontology Department of Medicine School of Medicine and Public Health University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy J.","family":"Kind","sequence":"additional","affiliation":[{"name":"Center for Health Disparities Research University of Wisconsin\u2010Madison  Madison Wisconsin USA"},{"name":"Wisconsin Alzheimer's Disease Research Center School of Medicine and Public Health University of Wisconsin\u2010Madison  Madison Wisconsin USA"},{"name":"Division of Geriatrics and Gerontology Department of Medicine School of Medicine and Public Health University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara B.","family":"Bendlin","sequence":"additional","affiliation":[{"name":"Center for Health Disparities Research University of Wisconsin\u2010Madison  Madison Wisconsin USA"},{"name":"Wisconsin Alzheimer's Institute School of Medicine and Public Health University of Wisconsin\u2010Madison  Madison Wisconsin USA"},{"name":"Wisconsin Alzheimer's Disease Research Center School of Medicine and Public Health University of Wisconsin\u2010Madison  Madison Wisconsin USA"},{"name":"Division of Geriatrics and Gerontology Department of Medicine School of Medicine and Public Health University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pallavi","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Department of Radiology School of Medicine and Public Health University of Wisconsin\u2010Madison  Madison Wisconsin USA"},{"name":"William S. Middleton Memorial Veterans Affairs (VA) Healthcare  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,20]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"US Department of Health and Human Services.Healthy people 2020: an opportunity to address societal determinants of health in the United States.US Department of Health and Human Services;2010.healthypeople.gov\/2010\/hp2020\/advisory\/SocietalDeterminantsHealth.htm"},{"key":"e_1_2_8_3_1","unstructured":"World Health Organization.A conceptual framework for action on the social determinants of health: debates policy & practice case studies.2010. 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