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This study aimed to clarify whether sleep quality or sleep duration affect amyloid beta (A\u03b2) and tau levels in plasma, cerebrospinal fluid (CSF), and positron emission tomography (PET) in non\u2010demented populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>PubMed, Web of Science, and Embase were systematically searched up to February 2025.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>In total, 30 studies were included comprising 14,997 subjects. Individuals with poor sleep quality exhibited greater PET A\u03b2 burden and higher A\u03b242 levels in plasma than those with good sleep quality. Shorter sleep duration was associated with higher A\u03b2 burden on PET. However, no association between either sleep quality or sleep duration and tau levels was found.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Sleep may be a modifiable marker of early AD management by modulating A\u03b2 levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>lPoor sleep quality and shorter sleep duration were significantly associated with higher amyloid beta (A\u03b2) burden detected by positron emission tomography (PET) in non\u2010demented populations. Poor sleep quality was also associated with elevated A\u03b242 levels in plasma.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>lNo significant associations were found between sleep quality or sleep duration and tau levels in plasma, cerebrospinal fluid, or PET.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>lInterventions targeting sleep could serve as a viable and low\u2010cost prevention strategy for early management of Alzheimer's disease.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  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