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However, the associated brain structural changes remain poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We analyzed T1\u2010weighted and diffusion tensor imaging in 33 idiopathic POI women and 51 healthy controls, using voxel\u2010based, surface\u2010based morphometry, and network analyses to assess gray matter volume (GMV), cortical thickness, and brain connectivity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Women with POI showed significant GMV and cortical thickness reductions in the frontal, parietal, and temporal regions (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05), alongside impaired connectivity with key regions such as the hippocampus, thalamus, and amygdala (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). Younger POI subgroups exhibited changes in more widespread brain regions. In additionally, notable atrophy was observed in specific hippocampal and thalamic subregions in POI (\n                      <jats:italic>p<\/jats:italic>\n                      &lt;\u00a00.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>This preliminary study suggests early neurodegenerative patterns in POI, potentially contributing to dementia risk. Further research is needed to explore the underlying mechanisms and potential interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>We evaluated brain structural changes in participants with idiopathic premature ovarian insufficiency (POI).<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The observed brain alterations in POI participants closely resemble those seen in early dementia, including regions specifically associated with Alzheimer's disease (AD).<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>These findings highlight the critical need for early interventions to reduce the long\u2010term risks of cognitive impairment and dementia in women with POI.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70111","type":"journal-article","created":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T23:49:17Z","timestamp":1743292157000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Brain structural alterations in young women with premature ovarian insufficiency: Implications for dementia risk"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1986-4090","authenticated-orcid":false,"given":"Shuang","family":"Yuan","sequence":"first","affiliation":[{"name":"The International Peace Maternity and Child Health Hospital, School of Medicine Shanghai Jiao Tong University Shanghai China"},{"name":"Shanghai Key Laboratory of Embryo 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