{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:05:59Z","timestamp":1789560359724,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["NIA R01 AG051545"],"award-info":[{"award-number":["NIA R01 AG051545"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["NIA R01 AG061093"],"award-info":[{"award-number":["NIA R01 AG061093"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["AACSF\u201021\u2010850735"],"award-info":[{"award-number":["AACSF\u201021\u2010850735"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Amyloid beta (A\u03b2) can be detected in vivo years before Alzheimer's disease (AD) symptom onset and, according to recent criteria, is sufficient for a biological diagnosis. This study evaluates emotional responses to A\u03b2 status disclosure in cognitively normal individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Questionnaires were given before and 6 months after A\u03b2 positron emission tomography results disclosure to assess anxiety and depression related to the possibility of an elevated result, subjective memory complaints, and motivation for risk\u2010reduction behavior.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      One hundred ninety\u2010nine cognitively normal adults were included. Non\u2010elevated A\u03b2 status disclosure was associated with reductions in all emotional parameters compared to baseline (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Elevated A\u03b2 disclosure was associated with no changes in depression or memory complaints and a modest decrease in anxiety and motivation to change lifestyle (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.048).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>No negative psychological effects were observed after A\u03b2 status disclosure. Decreased motivation for lifestyle changes was seen after disclosure of both elevated and non\u2010elevated amyloid status and should be targeted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>No negative psychological effects were observed after amyloid beta (A\u03b2) status disclosure.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Motivation for lifestyle changes decreased after A\u03b2 disclosure.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Lower education may predict \u201cunfavorable\u201d response to non\u2010elevated A\u03b2 disclosure.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Results support personalized communication strategies for A\u03b2 disclosure.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70115","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T07:00:16Z","timestamp":1746601216000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Emotional response to amyloid beta status disclosure among research participants at high dementia risk"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7610-2746","authenticated-orcid":false,"given":"Sapir","family":"Golan Shekhtman","sequence":"first","affiliation":[{"name":"The Joseph Sagol Neuroscience Center Sheba Medical Center  Ramat Gan Israel"},{"name":"Faculty of Medicine and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal Schnaider","family":"Beeri","sequence":"additional","affiliation":[{"name":"Krieger Klein Alzheimer's Research Center Brain Health Institute  Piscataway New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramit Ravona","family":"Springer","sequence":"additional","affiliation":[{"name":"The Joseph Sagol Neuroscience Center Sheba Medical Center  Ramat Gan Israel"},{"name":"Faculty of Medicine and Health Sciences Tel Aviv University  Tel Aviv Israel"},{"name":"Memory Clinic Sheba Medical Center  Ramat Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Zadok","sequence":"additional","affiliation":[{"name":"The Joseph Sagol Neuroscience Center Sheba Medical Center  Ramat Gan 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Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tal","family":"Niv","sequence":"additional","affiliation":[{"name":"The Joseph Sagol Neuroscience Center Sheba Medical Center  Ramat Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adar","family":"Matatov","sequence":"additional","affiliation":[{"name":"The Joseph Sagol Neuroscience Center Sheba Medical Center  Ramat Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Heymann","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Maccabi Health Services  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Azuri","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences Tel Aviv University  Tel Aviv Israel"},{"name":"Department of Family Medicine Maccabi Health Services  Tel Aviv 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