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However, African populations remain underrepresented in induced pluripotent stem cell (iPSC) collections, limiting the exploration of population\u2010specific disease mechanisms and therapeutic discoveries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>To address this gap, we established an open\u2010access African Somatic and Stem Cell Bank.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      In this initial phase, we generated 10 rigorously characterized iPSC lines from fibroblasts representing five Nigerian ethnic groups and both sexes. These lines underwent extensive profiling for pluripotency, genetic stability, differentiation potential, and Alzheimer's disease and Parkinson's disease risk variants. Clustered regularly interspaced palindromic repeats (CRISPR)\/CRISPR\u2010associated protein 9 technology was used to introduce frontotemporal dementia\u2010associated\n                      <jats:italic>MAPT<\/jats:italic>\n                      mutations (P301L and R406W).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>This collection offers a renewable, genetically diverse resource to investigate disease pathogenicity in African populations, facilitating breakthroughs in neurodegenerative research, drug discovery, and regenerative medicine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>We established an open\u2010access African Somatic and Stem Cell Bank.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>10 induced pluripotent stem cell lines from five Nigerian ethnic groups were rigorously characterized.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            Clustered regularly interspaced palindromic repeats (CRISPR)\/CRISPR\u2010associated protein 9 technology was used to introduce frontotemporal dementia\u2010causing\n                            <jats:italic>MAPT<\/jats:italic>\n                            mutations.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The African Somatic and Stem Cell Bank is a renewable, genetically diverse resource for neurodegenerative research.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70145","type":"journal-article","created":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T05:46:51Z","timestamp":1744436811000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Somatic and Stem Cell Bank to study the contribution of African ancestry to dementia: African iPSC Initiative"],"prefix":"10.1002","volume":"21","author":[{"given":"Mahmoud B.","family":"Maina","sequence":"first","affiliation":[{"name":"Biomedical Science Research and Training Centre Yobe State University  Damaturu Nigeria"},{"name":"Sussex Neuroscience School of Life Sciences University of Sussex  Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murtala 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