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Dementia"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>We investigated whether depression modified the associations between sleep duration and cognitive performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We examined the associations between sleep duration and cognition in 1853 dementia\u2010and\u2010stroke\u2010free participants (mean age 49.8 years, [range 27\u201385]; 42.7% male). Participants were categorized into four groups: no depressive symptoms, no antidepressants; depressive symptoms without antidepressant use; antidepressant use without depressive symptoms; and depressive symptoms and antidepressant use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Long sleep was associated with reduced overall cognitive function (\u03b2\u00a0\u00b1\u00a0standard error\u00a0=\u00a0\u22120.25\u00a0\u00b1\u00a00.07,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), with strongest effects in those with depressive symptoms using (\u22120.74\u00a0\u00b1\u00a00.30,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.017) and not using antidepressants (\u22120.60\u00a0\u00b1\u00a00.26,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.024). Weaker but significant effects were observed in those without depressive symptoms (\u22120.18\u00a0\u00b1\u00a00.09,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.044). No significant associations were observed in participants using antidepressants without depressive symptoms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Associations between sleep duration and cognitive performance are strongest in individuals with depressive symptoms, regardless of antidepressant use. Future research should elucidate underlying mechanisms and temporal relationships.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Sleeping \u2265 9\u00a0hours\/night was associated with worse cognitive performance.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>This association was stronger among those with depression.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Long sleepers were more likely to report symptoms of depression.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Sleep may be a modifiable risk for cognitive decline in people with depression.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70160","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T07:05:21Z","timestamp":1745219121000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Long sleep duration, cognitive performance, and the moderating role of depression: A cross\u2010sectional analysis in the Framingham Heart Study"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4633-5052","authenticated-orcid":false,"given":"Vanessa M.","family":"Young","sequence":"first","affiliation":[{"name":"Glenn Biggs Institute for Alzheimer's &amp; 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