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We aimed to investigate the involvement of Alzheimer's disease (AD) and non\u2010AD tau pathologies in LLMD participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Fifty\u2010two LLMD participants and 47 age\u2010 and sex\u2010matched healthy controls (HCs) underwent tau and amyloid beta (A\u03b2) positron emission tomography (PET) imaging using <jats:sup>18<\/jats:sup>F\u2010florzolotau and <jats:sup>11<\/jats:sup>C\u2010Pittsburgh compound B. Additionally, we conducted a clinicopathological correlation analysis in 208 autopsy cases, including various neurodegenerative diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>LLMD participants were more likely to be tau PET and A\u03b2 PET positive than HCs. The PET results were supported by the <jats:italic>post mortem<\/jats:italic> results that showed a higher likelihood of diverse tauopathies in patients with late\u2010life mania or depression than those without.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Our PET and autopsy assays suggest that AD and diverse non\u2010AD tau pathologies might underlie the neuropathological basis of some LLMD cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Late\u2010life mood disorders (LLMDs) may represent prodromal states of dementia.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The neuropathological basis of LLMDs remains unclear.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>LLMD subjects were highly likely to be tau positron emission tomography (PET) positive.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Brain bank data supported our PET 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