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Survival analyses examined the progression to MCI\/DE and death events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      LA\/CA use is associated with lower levels of CSF amyloid beta, phosphorylated\u2010tau (p\u2010tau) and total\u2010tau. After adjusting for age, sex, and apolipoprotein E (APOE) \u03b54 allele presence, that effect was quantified by negative coefficients of the fitted linear mixed models:\n                      <jats:italic>p<\/jats:italic>\n                      \u2010values\u00a0&lt;\u00a00.01 in all cases except for p\u2010tau in the MCI subgroup (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02). No similar effects were identified for other antiparkinsonians. Exposure to LA\/CA decreased the progression from MCI to DE (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.03).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>The identified association between LA\/CA exposure, AD biomarkers, and progression deserves further investigation in controlled clinical trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>LA\/CA is associated with lower levels of CSF biomarkers for AD.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>This effect is not observed when other antiparkinsonian drugs are used.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>LA\/CA is also associated with delayed progression to dementia by AD patients with MCI.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70213","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:51Z","timestamp":1747094451000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Association between the use of levodopa\/carbidopa, Alzheimer's disease biomarkers, and cognitive decline among participants in the National Alzheimer's Coordinating Center Uniform Data Set"],"prefix":"10.1002","volume":"21","author":[{"given":"Zsuzsa","family":"S\u00e1rk\u00e1ny","sequence":"first","affiliation":[{"name":"i3S \u2013 Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade Universidade do Porto  Porto Portugal"},{"name":"IBMC \u2013 Instituto de Biologia Molecular e Celular Universidade do Porto  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana","family":"Dam\u00e1sio","sequence":"additional","affiliation":[{"name":"i3S \u2013 Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade Universidade do Porto  Porto Portugal"},{"name":"Centro de Gen\u00e9tica Preditiva e Preventiva (CGPP) IBMC Universidade do Porto  Porto Portugal"},{"name":"Neurology Department Centro Hospitalar Universit\u00e1rio de Santo Ant\u00f3nio, ULS de Santo Ant\u00f3nio  Porto Portugal"},{"name":"ICBAS School of Medicine and Biomedical Sciences Universidade do Porto  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Macedo\u2010Ribeiro","sequence":"additional","affiliation":[{"name":"i3S \u2013 Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade Universidade do Porto  Porto Portugal"},{"name":"IBMC \u2013 Instituto de Biologia Molecular e Celular Universidade do Porto  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6908-1828","authenticated-orcid":false,"given":"Pedro M.","family":"Martins","sequence":"additional","affiliation":[{"name":"i3S \u2013 Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade Universidade do Porto  Porto Portugal"},{"name":"IBMC \u2013 Instituto de Biologia Molecular e Celular Universidade do Porto  Porto 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