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Aluminum chloride is a widely recognized neurotoxin and has been used as an animal model of Alzheimer's disease via mechanisms linked with oxidative stress and inflammation. The study investigated the potential ameliorative effect of apigenin on AlCl\n                      <jats:sub>3<\/jats:sub>\n                      \u2010induced neurotoxicity in rats.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Forty adult male Wistar rats were randomly divided into four different groups \u2013 control, AlCl\n                      <jats:sub>3<\/jats:sub>\n                      (100\u00a0mg\/kg), apigenin (50\u00a0mg\/kg) plus AlCl\n                      <jats:sub>3<\/jats:sub>\n                      , and apigenin (50\u00a0mg\/kg) alone administered orally for 14 days.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Our findings revealed AlCl\n                      <jats:sub>3<\/jats:sub>\n                      exposure induced significant neurobehavioral deficits, oxidative stress, neuroinflammation, and loss of the Purkinje cell layer of the cerebellum. Treatment with apigenin attenuated neuroinflammation and enhanced learning and memory with significant improvement in recognition index.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>\n                      Apigenin demonstrates promising ameliorative effects against AlCl\n                      <jats:sub>3<\/jats:sub>\n                      \u2010induced neurotoxicity in rats.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Aluminum chloride toxicity caused significant reduction in learning, exploration, and memory.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Aluminum chloride toxicity induced neurotoxicity, increased biomarkers of oxidative stress, neuroinflammation, and precipitated cognitive impairment.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Apigenin improved brain antioxidant, enhanced learning, exploration, and memory.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70223","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T09:58:04Z","timestamp":1746179884000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Apigenin mitigates oxidative stress, neuroinflammation, and cognitive impairment but enhances learning and memory in aluminum chloride\u2010induced 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