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Dementia"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Although a vast amount of magnetic resonance imaging (MRI) data are collected for health care delivery, generating real\u2010world evidence (RWE) in Alzheimer's disease and related dementias (ADRD) research is substantially limited by lack of methods and results showing how routine MRI scans can be used for ADRD imaging studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      We compared three established ADRD biomarkers (total gray matter, hippocampal, and ventricular volumes) in four groups (normal, subjective complaints, mild cognitive impairment [MCI], and dementia) between the general population of women born in 1932\u20131941 in the Kuopio region of Eastern Finland (population\u2010based Kuopio Osteoporosis Risk Factor and Prevention Study [OSTPRE] cohort,\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a014220) and a well\u2010characterized research cohort (Alzheimer's Disease Neuroimaging Initiative [ADNI]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>A total of 2434 brain MRI scans for 1885 women were collected between 2003 and 2022 by the public health care provider covering all residents in the region. The established biomarkers were overall aligned between these cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Typical biomarkers extracted from real\u2010world brain MRI scans collected over 20 years are suitable for generating RWE in ADRD research.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Real\u2010world brain magnetic resonance imaging (MRI) is applicable for generating evidence in Alzheimer's disease and related dementias (ADRD) research.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>This is the first study comparing a real\u2010world MRI cohort with an established research cohort reference.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Provides a methodological framework for real\u2010world evidence (RWE) ADRD studies that utilize routinely collected MRI scans.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70227","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T06:35:17Z","timestamp":1753252517000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Real\u2010world brain imaging in a population\u2010based cohort enables accurate markers for dementia"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6268-8117","authenticated-orcid":false,"given":"Reijo","family":"Sund","sequence":"first","affiliation":[{"name":"Institute of Clinical Medicine University of Eastern Finland  Kuopio Finland"},{"name":"Knowledge Management Unit Kuopio University Hospital  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juho","family":"Sepp\u00e4nen","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine University of Eastern Finland  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaheh","family":"Moradi","sequence":"additional","affiliation":[{"name":"A.I. 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