{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T01:08:04Z","timestamp":1782954484511,"version":"3.54.5"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:00:00Z","timestamp":1749600000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000179","name":"Office of the Director","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000179","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>Longitudinal electronic health records (EHRs), \u201cdementia\u201d diagnostic codes, and genetic data from <jats:italic>All of Us<\/jats:italic> were used to see if there is a higher risk of dementia and an attenuated impact of apolipoprotein <jats:italic>\u03b54<\/jats:italic> (APOE4) on Alzheimer's disease (AD) risk in Black and Hispanic\/Latino groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Participants included 9,784 Hispanic\/Latinos, 14,937 Non\u2010Hispanic Blacks (NHB), and 60,388 Non\u2010Hispanic Whites (NHWs) \u2265age 60 without an initial dementia diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>There was a significantly higher risk of developing a dementia diagnosis in Hispanic\/Latino and NHB participants than NHW participants and comparably increased dementia hazard ratios in the Hispanic\/Latino, NHB, and NHW APOE4 carriers than non\u2010carriers (hazard ratio [HR] [95% confidence interval {CI}] 1.54 [1.25\u20131.91], 1.25 [1.00\u20131.57], and 1.55 [1.40\u20131.72]).<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Compared to NHW individuals, Hispanic\/Latino and NHB individuals are at higher risk of developing a \u201cdementia diagnosis\u201d and comparably higher risk in APOE4 carriers than non\u2010carriers. Plasma AD biomarkers could clarify the proportion of dementia cases with and without AD and the impact of APOE4 on AD in these groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Hispanic\/Latino and non\u2010Hispanic Black individuals have a higher risk of all\u2010cause dementia.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The impact of apolipoprotein <jats:italic>\u03b54<\/jats:italic> (APOE4) on dementia risk was similar in the studied ethnoracial groups.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Plasma biomarkers could inform the risk of Alzheimer's disease (AD) and impact of APOE4 in these groups.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.70245","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T02:54:08Z","timestamp":1749696848000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of APOE4\u2010related dementia risk in underrepresented groups from the <i>All of Us<\/i> research program"],"prefix":"10.1002","volume":"21","author":[{"given":"Valentina","family":"Ghisays","sequence":"first","affiliation":[{"name":"Banner Alzheimer's Institute  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehsan","family":"Khajouei","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice and Science, R. Ken Coit College of Pharmacy University of Arizona  Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignazio S.","family":"Piras","sequence":"additional","affiliation":[{"name":"Early Detection and Prevention Division Translational Genomics Research Institute  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H.","family":"Malek\u2010Ahmadi","sequence":"additional","affiliation":[{"name":"Banner Alzheimer's Institute  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hillary D.","family":"Protas","sequence":"additional","affiliation":[{"name":"Banner Alzheimer's Institute  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhruman D.","family":"Goradia","sequence":"additional","affiliation":[{"name":"Banner Alzheimer's Institute  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghua","family":"Chen","sequence":"additional","affiliation":[{"name":"Banner Alzheimer's Institute  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Naymik","sequence":"additional","affiliation":[{"name":"Early Detection and Prevention Division Translational Genomics Research Institute  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald","family":"Saner","sequence":"additional","affiliation":[{"name":"Banner Alzheimer's Institute  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia J.","family":"Veatch","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Physiology University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clayton O.","family":"Mansel","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Physiology University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Su","sequence":"additional","affiliation":[{"name":"Banner Alzheimer's Institute  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Huentelman","sequence":"additional","affiliation":[{"name":"Early Detection and Prevention Division Translational Genomics Research Institute  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason H.","family":"Karnes","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice and Science, R. 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