{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:06:21Z","timestamp":1791860781474,"version":"4.3.4"},"reference-count":81,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:00:00Z","timestamp":1749600000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201017\u2010JPCD\u20100003"],"award-info":[{"award-number":["ANR\u201017\u2010JPCD\u20100003"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["COEN\u20100002"],"award-info":[{"award-number":["COEN\u20100002"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["COEN\u20104024"],"award-info":[{"award-number":["COEN\u20104024"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201010\u2010AIHU\u201006"],"award-info":[{"award-number":["ANR\u201010\u2010AIHU\u201006"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["PID2022\u2010141900OB\u2010I00"],"award-info":[{"award-number":["PID2022\u2010141900OB\u2010I00"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["AC170006"],"award-info":[{"award-number":["AC170006"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["ZonMW 733051072"],"award-info":[{"award-number":["ZonMW 733051072"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/R024901\/1"],"award-info":[{"award-number":["MR\/R024901\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["CEX2020\u2010001049\u2010S,MCIN\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["CEX2020\u2010001049\u2010S,MCIN\/AEI\/10.13039\/501100011033"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["CERCA"],"award-info":[{"award-number":["CERCA"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>The <jats:italic>locus coeruleus<\/jats:italic> (LC), the brain's primary source of noradrenaline (NA), undergoes early neurodegeneration in Parkinson's disease (PD), Alzheimer's diseases (AD), and Down syndrome (DS); however, differences have not been examined in parallel.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p><jats:italic>Post mortem<\/jats:italic> brains (<jats:italic>n<\/jats:italic>\u00a0=\u00a067) from individuals with AD, DS\u2010AD, and PD without and with dementia (PD\u2010D) and controls were analyzed for amyloid beta (A\u03b2), phosphorylated tau (pTau), \u03b1\u2010synuclein, endo\u2010lysosomal alterations, biogenic amines, and selective biomarkers.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>LC degeneration correlated with age, peaking in AD and PD\u2010D, while NA and dopaminergic metabolites were significantly reduced only in PD\u2010D. DS\u2010AD, the youngest group, showed the highest A\u03b2 and pTau levels but the least noradrenergic neuron loss. We demonstrated for the first time that endosomal alterations were present in AD, lysosomal changes were present in PD\u2010D\/DS\u2010AD, and DYRK1A, a key protein from chromosome 21, was elevated only in DS\u2010AD.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Loss of noradrenergic neurons may occur independently of amyloid and tau pathologies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>We provide the first analysis of neuropathological and biochemical features including biogenic amines of the LC in AD, DS, and PD.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Loss of noradrenergic neurons was most severe in AD and PD.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Only in DS, levels of DYRK1A \u2013 a kinase encoded on chromosome 21 and implicated in neurodegenerative processes \u2013 were elevated and negatively correlated to biogenic amine levels.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Although individuals with DS having AD were the youngest group, they had the highest levels of amyloid and tau pathologies, but less noradrenergic neurons loss compared to other disease groups.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.70262","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T11:11:14Z","timestamp":1749726674000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Disease\u2010specific neuropathological alterations of the <i>locus coeruleus<\/i> in Alzheimer's disease, Down syndrome, and Parkinson's disease"],"prefix":"10.1002","volume":"21","author":[{"given":"Marta","family":"Fructuoso","sequence":"first","affiliation":[{"name":"Sorbonne Universit\u00e9, Institut du Cerveau \u2010 Paris Brain Institute \u2010 ICM CNRS, APHP, H\u00f4pital de La Piti\u00e9\u2010Salp\u00eatri\u00e8re, INSERM  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannick","family":"Vermeiren","sequence":"additional","affiliation":[{"name":"Laboratory of Neurochemistry and Behavior Experimental Neurobiology Unit Department of Biomedical Sciences University of Antwerp  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Boluda","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Institut du Cerveau \u2010 Paris Brain Institute \u2010 ICM CNRS, APHP, H\u00f4pital de La Piti\u00e9\u2010Salp\u00eatri\u00e8re, INSERM  Paris France"},{"name":"Laboratoire de Neuropathologie R Escourolle H\u00f4pital de la Piti\u00e9\u2010Salp\u00eatri\u00e8re AP\u2010HP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lev","family":"Stimmer","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Institut du Cerveau \u2010 Paris Brain Institute \u2010 ICM CNRS, APHP, H\u00f4pital de La Piti\u00e9\u2010Salp\u00eatri\u00e8re, INSERM  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9 A. J.","family":"Crans","sequence":"additional","affiliation":[{"name":"Center for Genomic Regulation (CRG) The Barcelona Institute for Science and Technology Carrer del Doctor Aiguader  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Xicota","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Institut du Cerveau \u2010 Paris Brain Institute \u2010 ICM CNRS, APHP, H\u00f4pital de La Piti\u00e9\u2010Salp\u00eatri\u00e8re, INSERM  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uli","family":"Eisel","sequence":"additional","affiliation":[{"name":"Department of Molecular Neurobiology Groningen Institute of Evolutionary Life Science Faculty of Science and Engineering University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia Orti","family":"Casan","sequence":"additional","affiliation":[{"name":"Department of Molecular Neurobiology Groningen Institute of Evolutionary Life Science Faculty of Science and Engineering University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Bun","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry and Neuroscience of Paris (IPNP) Universit\u00e9 Paris Cit\u00e9 INSERM U1266, NeurImag Core Facility  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Duyckaerts","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Institut du Cerveau \u2010 Paris Brain Institute \u2010 ICM CNRS, APHP, H\u00f4pital de La Piti\u00e9\u2010Salp\u00eatri\u00e8re, INSERM  Paris France"},{"name":"Laboratoire de Neuropathologie R Escourolle H\u00f4pital de la Piti\u00e9\u2010Salp\u00eatri\u00e8re AP\u2010HP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Maurice","family":"Delabar","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Institut du Cerveau \u2010 Paris Brain Institute \u2010 ICM CNRS, APHP, H\u00f4pital de La Piti\u00e9\u2010Salp\u00eatri\u00e8re, INSERM  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Strydom","sequence":"additional","affiliation":[{"name":"Department of Forensic and Neurodevelopmental Sciences Institute of Psychiatry Psychology &amp; Neuroscience King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debby","family":"Van Dam","sequence":"additional","affiliation":[{"name":"Laboratory of Neurochemistry and Behavior Experimental Neurobiology Unit Department of Biomedical Sciences University of Antwerp  Antwerp Belgium"},{"name":"Department of Neurology and Alzheimer Center University Medical Center Groningen University of Groningen  Gronongen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Dierssen","sequence":"additional","affiliation":[{"name":"Department of Molecular Neurobiology Groningen Institute of Evolutionary Life Science Faculty of Science and Engineering University of Groningen  Groningen The Netherlands"},{"name":"Department of Experimental and Health Sciences University Pompeu Fabra  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"De Deyn","sequence":"additional","affiliation":[{"name":"Laboratory of Neurochemistry and Behavior Experimental Neurobiology Unit Department of Biomedical Sciences University of Antwerp  Antwerp Belgium"},{"name":"Department of Neurology and Alzheimer Center University Medical Center Groningen University of Groningen  Gronongen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Claude","family":"Potier","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Institut du Cerveau \u2010 Paris Brain Institute \u2010 ICM CNRS, APHP, H\u00f4pital de La Piti\u00e9\u2010Salp\u00eatri\u00e8re, INSERM  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2022.895481"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2110630118"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0047\u20106374(83)90100\u20108"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology11121822"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010240043"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035\u2010023\u201000347\u2010z"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2017.09.035"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010142682"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2016.11.009"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3983"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010007\u20100336\u20100"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26191"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531\u20108249(199903)45:3<353::aid\u2010ana11>3.0.co;2\u20104"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2014.05.004"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010023\u201002657\u2010y"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.14456"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478\u2010020\u201000956\u2010z"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-16-06142.1997"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2015.87"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010023\u201002355\u2010z"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478\u2010020\u201000935\u20104"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26321"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0578\u201019.2019"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2024.1380483"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101414"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010023\u201002419\u20100"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12046"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI130513"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902870308"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2017.11.001"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102011\u2010301817"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12386"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12387"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2006.02.007"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e318232a379"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2005.03.020"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1101\/2024.10.31.24316469"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2014.61"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10061380"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/8848642"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010215057"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478\u2010017\u20100411\u20102"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11\u2010202457"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410320510"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.06.2362"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16\u201001\u201000186.1996"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0002\u20109440(10)64538\u20105"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.164152"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12325"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlw002"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010231328"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1159\/000354670"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.4172\/2161\u20100460.1000444"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD\u2010212748"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010024\u201002756\u20104"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010019\u20100143\u20107"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471\u20104159.2007.05075.x"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201046876\u20107"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0197\u20104580(97)00035\u20103"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0197\u20104580(97)00034\u20101"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102990.2006.00756.x"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896\u20106273(95)90324\u20100"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.071053"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u20102010\u2010101080"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/62.5.451"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1500937112"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0167428"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2018.02.019"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010140783"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1468\u201019.2020"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.100867"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00161"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010017\u20100591\u20106"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25236"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1107411108"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2013.00096"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102022\u2010329136"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(16)30034\u20105"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2023.116098"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c02068"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2022.866434"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.70262","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T11:16:13Z","timestamp":1760008573000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.70262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":81,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/alz.70262"],"URL":"https:\/\/doi.org\/10.1002\/alz.70262","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"2024-12-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70262"}}