{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T19:32:24Z","timestamp":1784835144100,"version":"3.55.0"},"reference-count":64,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFC2421100"],"award-info":[{"award-number":["2024YFC2421100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>Dementia, particularly Alzheimer's disease, involves cognitive decline linked to amyloid beta (A\u03b2) and tau protein aggregation. Magnetic resonance imaging (MRI)\u2010based brain tissue conductivity, which increases in dementia, may serve as a non\u2010invasive biomarker for protein aggregation. We investigate the relationship between MRI\u2010based brain electrical conductivity, protein aggregation, cognition, and gene expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Brain conductivity maps were reconstructed and correlated with PET protein signals, cognitive performance, and plasma protein levels. The diagnostic potential of conductivity for dementia was assessed, and transcriptomic analysis using the Allen Human Brain Atlas elucidated the underlying biological processes.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Increased brain conductivity was associated with A\u03b2 and tau aggregation in specific brain regions, cognitive decline, and plasma protein levels. Conductivity also improved dementia discrimination performance, and higher gene expression related to ion transport, cellular development, and signaling pathways was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Brain electrical conductivity shows promise as a biomarker for dementia, correlating with protein aggregation and relevant cellular processes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Brain tissue conductivity correlates with A\u03b2 and tau aggregation in dementia.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Brain tissue conductivity correlates with cognitive scores and GMV.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>CSF conductivity correlates with plasma protein levels.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Combining conductivity with GMV improves dementia diagnosis accuracy.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Gene expression in ion processes, cell development, and signaling links to conductivity.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.70270","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T23:45:23Z","timestamp":1750722323000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Brain tissue electrical conductivity as a promising biomarker for dementia assessment using MRI"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0799-8706","authenticated-orcid":false,"given":"Jiayue","family":"Chu","sequence":"first","affiliation":[{"name":"School of Biomedical Engineering Shanghai Jiao Tong University  Shanghai 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