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Fiber density was reduced in PDD versus DLB, but neither plasma measures nor fiber cross\u2010section differed between LBD subtypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Our findings suggest that the presence of dementia in LBD is associated with poorer white matter macrostructure and may relate to pathological protein accumulation. Conversely, differences between DLB and PDD may be driven by other factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Plasma neurofilament light and phosphorylated tau\u2010217 were increased in Lewy body dementia (LBD) relative to Parkinson's disease (PD) and controls.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Magnetic resonance imaging (MRI) white matter macrostructure (fiber cross\u2010section) was reduced in LBD relative to PD.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>In contrast, MRI white matter microstructure (fiber density) was reduced in PD dementia compared to dementia with Lewy bodies.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Differences between dementia with Lewy bodies and PD dementia were distinct compared with those between LBD and Parkinson's with normal cognition.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Our findings suggest that dementia with Lewy bodies and Parkinson's dementia differ in underlying processes distinct from those driving dementia.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70274","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T14:35:12Z","timestamp":1747924512000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Neuroimaging and plasma biomarker differences and commonalities in Lewy body dementia subtypes"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8608-7757","authenticated-orcid":false,"given":"Naomi","family":"Hannaway","sequence":"first","affiliation":[{"name":"Dementia Research Centre UCL Institute of Neurology  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angeliki","family":"Zarkali","sequence":"additional","affiliation":[{"name":"Dementia Research Centre UCL Institute of Neurology  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohan","family":"Bhome","sequence":"additional","affiliation":[{"name":"Dementia Research Centre UCL Institute of Neurology  London UK"},{"name":"UCL Hawkes Institute Department of Computer Science  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivelina","family":"Dobreva","sequence":"additional","affiliation":[{"name":"Dementia Research Centre UCL Institute of Neurology  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George E. 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