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decline across a robust neuropsychological protocol over a 9\u2010year period.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Vanderbilt Memory and Aging Project participants (<jats:italic>n<\/jats:italic>\u00a0=\u00a0336, 73\u00a0\u00b1\u00a07 years, 59% male, 87% non\u2010Hispanic White, 10% Black\/African American) underwent blood draw for baseline plasma protein abundance using mass spectrometry analysis of tandem mass tag (TMT)\u2010labeled peptides and serial neuropsychological assessment (follow\u2010up\u00a0=\u00a06.1\u00a0\u00b1\u00a02.3 years). Linear mixed\u2010effects regressions related protein levels to neuropsychological outcomes in fully adjusted models. False discovery rate correction was applied.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Initial proteomics analyses yielded 3764 unique protein identifications across 23 16\u2010plex TMT batches, and 686 proteins passed quality control. Proteins were identified predicting longitudinal decline in language (EGFR, RTN4RL2), information processing speed (EGFR, NOMO2, CLEC3B), executive function (A1BG), and visuospatial skills (RTN4RL2, GALNT1, SERPINA4, SERPINA5, C8A, ALDOB), but not episodic memory.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Large\u2010scale proteomics analyses identified 10 plasma proteins that predicted subsequent cognitive decline over a 9\u2010year follow\u2010up in multiple cognitive domains.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>There were 3764 unique protein identifications across 23 16\u2010plex TMT batches.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Rigorous quality control yielded 686 proteins used as predictors in analyses.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Identified proteins related to all domains assessed, except for episodic memory.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Many proteins identified were differentially expressed in MCI.\n<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.70276","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T05:02:12Z","timestamp":1749099732000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["LC\u2010MS\/MS proteomics identifies plasma proteins related to cognition over 9\u2010year follow\u2010up"],"prefix":"10.1002","volume":"21","author":[{"given":"Hailey A.","family":"Adegboye","sequence":"first","affiliation":[{"name":"Vanderbilt Memory and Alzheimer's Center Vanderbilt University School of Medicine  Nashville Tennessee USA"},{"name":"Medical Scientist Training Program Vanderbilt University School of Medicine  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khiry L.","family":"Patterson","sequence":"additional","affiliation":[{"name":"Department of Chemistry Vanderbilt University  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Libby","sequence":"additional","affiliation":[{"name":"Vanderbilt Memory and Alzheimer's Center Vanderbilt University School of Medicine  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyi","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panpan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Vanderbilt Memory and Alzheimer's Center Vanderbilt University School of Medicine  Nashville Tennessee USA"},{"name":"Department of Biostatistics Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Liu","sequence":"additional","affiliation":[{"name":"Vanderbilt Memory and Alzheimer's Center Vanderbilt University School of Medicine  Nashville Tennessee USA"},{"name":"Department of Biostatistics Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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