{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:53:38Z","timestamp":1790272418642,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U19AG078109"],"award-info":[{"award-number":["U19AG078109"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Sleep patterns change with aging, yet their relationship with brain health, particularly Alzheimer's disease (AD)\u2010related MRI patterns among diverse older adults is not clear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We cross\u2010sectionally studied community\u2010dwelling Non\u2010Hispanic White (NHW), Hispanic, and Black participants recruited from the Health and Aging Brain Study\u2010Health Disparities (HABS\u2010HD)\u2010Dormir Study, who underwent WatchPAT and brain MRI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>A total of 842 participants (34% male; 42% NHW, 33% Hispanic, and 25% Black; mean age 66.1 \u00b1 8.6 years) were included. Greater light sleep percentage and longer rapid\u2010eye movement (REM) sleep latency were independently associated with thinner cortex in AD\u2010signature regions, while inverse pattern was observed for greater deep sleep percentage. Higher Apnea\u2010Hypopnea Index (AHI) in REM sleep was independently associated with greater white matter hyperintensities volume. There were no ethnoracial interactions for these associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Light and deep sleep percentage, REM sleep latency, and AHI in REM sleep were associated with AD\u2010related MRI patterns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Greater light sleep percentage and longer rapid\u2010eye movement sleep latency were associated with thinner cortex in the Alzheimer's Disease\u2010siganture regions, while greater deep sleep percentage was associated with thicker cortex in those regions.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Higher apnea hypoonea index in rapid eye movement sleep was associated with greater white matter hyperintensities volume.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>No moderation effects by race\/ethnicity were observed among Non\u2010Hispanic White\/Hispanic\/Black adults.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70280","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T05:59:22Z","timestamp":1747720762000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Sleep macro\u2010architecture, nocturnal hypoxemia, and Alzheimer's disease\u2010related MRI patterns among diverse older adults"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3091-1932","authenticated-orcid":false,"given":"Dillys Xiaodi","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith N.","family":"Braskie","sequence":"additional","affiliation":[{"name":"Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9mence","family":"Cavaill\u00e8s","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie","family":"Peltz","sequence":"additional","affiliation":[{"name":"Northern California Institute for Research and Education  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Redline","sequence":"additional","affiliation":[{"name":"Division of Sleep Medicine and Circadian Disorders, Department of Medicine Brigham and Women's Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine","family":"Yaffe","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Neurology, and Epidemiology and Biostatistics University of California  San Francisco California 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