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Subsamples had creatinine (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0137) and positron emission tomography (PET; amyloid\u2010PET =\u00a065 [amyloid\u2010PET\u2010positive\u00a0=\u00a016\/65]; tau\u2010PET =\u00a070). We tested whether p\u2010tau217 (ALZPath, Inc.) varied by medical condition and amyloid\u2010 and tau\u2010PET\u2010positivity status and assessed the diagnostic accuracy of p\u2010tau217.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Estimated glomerular filtration rate (eGFR)\u00a0&lt;60\u00a0mL\/min\/1.73\u00a0m\n                      <jats:sup>2<\/jats:sup>\n                      , cardiovascular disease (CVD), and amyloid\u2010 and tau\u2010PET\u2010positive status demonstrated higher p\u2010tau217. Effect sizes (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sub>pb<\/jats:sub>\n                      ): eGFR\u00a0&lt;60 group\u00a0=\u00a00.48, CVD\u00a0=\u00a00.25, amyloid\u2010PET\u2010positive status\u00a0=\u00a00.54; tau\u2010PET\u2010positive status\u00a0=\u00a00.56. Lower eGFR was related to higher p\u2010tau217 when adjusting for amyloid\u2010PET. For abnormal amyloid\u2010PET and tau\u2010PET, p\u2010tau217 exhibited areas under the curve of 0.90 and 0.89, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Plasma p\u2010tau217 showed promise as an Alzheimer's biomarker in Black adults; however, kidney function and CVD should be considered when interpreting levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Plasma tau phosphorylated at threonine 217 (p\u2010tau217) was tested in a sample of Black middle\u2010aged and older adults.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Level of p\u2010tau217 was higher in impaired kidney function and cardiovascular disease.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Obesity and diabetes were not related to p\u2010tau217.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Level of p\u2010tau217 was higher in amyloid\u2010 and tau\u2010PET\u2010positive status.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Plasma p\u2010tau217 showed good receiver\u2010operating characteristic area under the curve for abnormal amyloid\u2010 and tau\u2010PET.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  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