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Longitudinal observations, coupled with different disease\u2010specific biomarkers to assess potential downstream effects of A\u03b2, have confirmed that \u0391\u03b2 deposition in the brain starts decades before the onset of symptoms. A\u03b2 imaging studies continue to refine our understanding of the role of \u0391\u03b2 deposition in AD, and its relation to other imaging and fluid biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>\u0391\u03b2 imaging revolutionized the in vivo assessment of Alzheimer's disease \u0391\u03b2 pathology.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\u0391\u03b2 imaging has increased our insights into A\u03b2 deposition in the brain by providing highly accurate, reliable, and reproducible quantitative statements of regional and global \u0391\u03b2 burden in the brain.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\u0391\u03b2 imaging is essential for the differential diagnosis, staging, and evaluation of disease\u2010specific anti\u2010\u0391\u03b2 therapeutic approaches.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\u0391\u03b2 imaging studies continue to refine our understanding of the role of \u0391\u03b2 deposition in Alzheimer's disease, and its relation to other imaging and fluid biomarkers.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70291","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T07:15:22Z","timestamp":1747984522000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A brief history of A\u03b2 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