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         <jats:p>\n                      Between 2016 and 2018, the Study of Latinos\u2010Investigation of Neurocognitive Aging (SOL\u2010INCA) enrolled diverse Hispanic\/Latino individuals ages 50 years and older (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a06377). Cognitive function, cognitive change, and mild cognitive impairment (MCI) were the primary outcomes. Chronic kidney disease (CKD, defined as estimated glomerular filtration rate [eGFR]\u00a0&lt;\u00a060\u00a0mL\/min per 1.73 m2 or urine albumin\u2010creatinine ratio [uACR]\u00a0\u2265\u00a030\u00a0mg\/g) and two independent secondary exposures (i.e., eGFR and uACR) were examined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>CKD was associated with lower cognitive function and 7\u2010year cognitive decline independent of diabetes and hypertension. CKD was associated with MCI, but the effect attenuated by adjustments for CVD risk factors. More albuminuria was associated with lower cognitive function, cognitive decline, independent of CVD risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>CKD and higher albuminuria were linked to lower cognitive function, cognitive decline, and elevated risk for MCI among diverse middle\u2010aged and older Hispanic\/Latino individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Kidney disease has garnered increased attention in interpreting blood\u2010based biomarkers of Alzheimer's disease and related disorders.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Hispanic\/Latino individuals are at increased risk for kidney disease.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>We found that urinary albumin\u2010to\u2010creatinine ratio outperformed estimated glomerular filtration in relation to cognitive function and impairment.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Our findings suggest that kidney dysfunction is an independent marker of cognitive function and impairment.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  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