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Moreover, rescue of neurological disease in STING\u2010deficient 5xFAD mice was characterized by reduced expression of type I interferon signaling genes in both microglia and excitatory neurons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>These findings reveal critical roles for STING in A\u03b2\u2010driven neurological disease and suggest that STING\u2010targeting therapeutics may offer promising strategies to treat AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Stimulator of interferon genes (STING) deficiency in the 5xFAD mouse model of Alzheimer's disease\u2010related amyloidosis results in decreased amyloid beta (A\u03b2) deposition and altered microglial activation status.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Protection against amyloidosis in STING\u2010deficient 5xFAD mice is associated with decreased expression of genes involved in type I IFN signaling, improved neuronal health, and reduced levels of oxidative stress.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Loss of STING in 5xFAD mice leads to improved spatial learning and memory.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  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