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Dementia"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>The Down syndrome\u2010associated Alzheimer's disease (DSAD) autosomal dominant Alzheimer's disease (ADAD) 2024 Conference in Barcelona, convened under an Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) grant through the Down syndrome and Alzheimer's disease (AD) Professional Interest Area (PIA), brought together global researchers to foster collaboration and knowledge exchange between the fields of DSAD and ADAD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>This article provides a synthesis review of the conference proceedings, summarizing key discussions on biomarkers, natural history models, clinical trials, and ethical considerations in anti\u2010amyloid therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>A total of 211 attendees from 16 countries joined the meeting. Global researchers presented on disease mechanisms, therapeutic developments, and patient care strategies. Discussions focused on challenges and opportunities unique to DSAD and ADAD. Experts emphasized the urgent need for tailored clinical trials for ADAD and DSAD and debated the safety and efficacy of anti\u2010amyloid treatments. Ethical considerations highlighted equitable access to therapies and the crucial role of patient and caregiver involvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>The conference highlighted the importance of inclusive research and collaboration across the genetic forms of AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Biomarker research and natural history models developed in Down syndrome\u2010associated Alzheimer's disease (DSAD) and autosomal dominant Alzheimer's disease (ADAD) enable the prediction of disease progression not only for DSAD and ADAD, but also for sporadic Alzheimer's disease (AD).<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\u2010Collaboration and knowledge exchange among researchers across these genetic forms of AD will accelerate our understanding of the pathophysiology and advance preventive trials in DSAD and ADAD.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\u2010Tailored clinical trials for DSAD are urgently needed to address specific safety and efficacy concerns.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\u2010Inclusive research practices are crucial for advancing treatments and understanding of DSAD and ADAD.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70309","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T23:35:43Z","timestamp":1751499343000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Genetically determined Alzheimer's disease research advances: The Down Syndrome &amp; Autosomal Dominant Alzheimer's Disease 2024 Conference"],"prefix":"10.1002","volume":"21","author":[{"given":"Neus","family":"Falg\u00e0s","sequence":"first","affiliation":[{"name":"Alzheimer's Disease and Other Cognitive Disorders Unit, Service of Neurology Hospital Cl\u00ednic de Barcelona Fundaci\u00f3 de Recerca Cl\u00ednic Barcelona\u2010Institut d'Investigaci\u00f3 Biom\u00e8dica August Pi i Sunyer University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5643-7971","authenticated-orcid":false,"given":"Lucia","family":"Maure\u2010Blesa","sequence":"additional","affiliation":[{"name":"Memory Unit Department of Neurology Hospital de la Santa Creu i Sant Pau Biomedical Research Institute Sant Pau Sant Antoni Maria Claret Departamento de Medicina Universitat Aut\u00f3noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beau","family":"Ances","sequence":"additional","affiliation":[{"name":"Department of Neurology Washington University School of Medicine in St. Louis St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisi","family":"Flores\u2010Aguilar","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of California Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigan","family":"Hartley","sequence":"additional","affiliation":[{"name":"Waisman Center University of Wisconsin\u2010Madison Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Hassenstab","sequence":"additional","affiliation":[{"name":"Department of Neurology Washington University School of Medicine in St. Louis St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Florencia","family":"Iulita","sequence":"additional","affiliation":[{"name":"Altoida Inc. Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Janicki","sequence":"additional","affiliation":[{"name":"Department of Disability and Human Development University of Illinois Chicago Chicago Illinois USA"},{"name":"National Task Group on Intellectual Disabilities and Dementia Practices Rockport Maine USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Koenig","sequence":"additional","affiliation":[{"name":"Imaging Sciences Imaging Institute Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Lao","sequence":"additional","affiliation":[{"name":"Gertrude H. 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