{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:06:49Z","timestamp":1789560409044,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T00:00:00Z","timestamp":1747958400000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007088","name":"Ralph C. Wilson Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007088","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014813","name":"Arizona Alzheimer's Consortium","doi-asserted-by":"publisher","award":["ADHS 11\u2010052688"],"award-info":[{"award-number":["ADHS 11\u2010052688"]}],"id":[{"id":"10.13039\/100014813","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG069453"],"award-info":[{"award-number":["AG069453"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>We previously demonstrated that single\u2010domain amnestic mild cognitive impairment (SDAm\u2010MCI) detected through longitudinal neuropsychological testing in our research cohort is less severe than in clinically incident symptomatic individuals. This study aims to replicate and expand this work using a National Alzheimer's Coordinating Center dataset.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Participants were classified into two groups: those enrolled with normal cognition (Normal Enrollees) and those enrolled with SDAm\u2010MCI (Amnestic Enrollees). Groups were compared at the time of diagnosis and on rates of cognitive decline post\u2010diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>At SDAm\u2010MCI diagnosis, Normal Enrollees were 17% to 39% less impaired on memory tasks, after which the slope of change over time steepened compared to their pre\u2010symptomatic change and was steeper than in Amnestic Enrollees.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Incident MCI detected through longitudinal neuropsychological testing is initially milder but may progress more steeply than in clinically established MCI. Sensitive assessment of cognitive decline is essential for capturing early changes that are more likely to be amenable to therapeutic treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Longitudinal cognitive evaluation detects symptomatic Alzheimer's disease earlier than mental status exams.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>At the time of diagnosis, converters were less impaired compared to initially symptomatic patients.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Converters\u2019 cognition declined more steeply than initially symptomatic patients.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Sensitive cognitive tests are essential to capture early changes, given new disease\u2010modifying therapies.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70317","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T23:54:48Z","timestamp":1748044488000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Longitudinal neuropsychological evaluation allows diagnosis of MCI with less severe memory change"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1966-7716","authenticated-orcid":false,"given":"Dona E. C.","family":"Locke","sequence":"first","affiliation":[{"name":"Division of Neuropsychology Mayo Clinic  Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blake","family":"Langlais","sequence":"additional","affiliation":[{"name":"Division of Clinical Trials and Biostatistics Department of Quantitative Health Sciences Mayo Clinic  Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dixie","family":"Woolston","sequence":"additional","affiliation":[{"name":"Division of Neuropsychology Mayo Clinic  Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan K.","family":"Woodruff","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic  Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia M.","family":"Stonnington","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology Mayo Clinic  Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Baxter","sequence":"additional","affiliation":[{"name":"Division of Neuropsychology Mayo Clinic  Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Caselli","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic  Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212948"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.13239"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2023.50"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.3838"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci7090112"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.3016"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617721000485"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci11080988"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/13854046.2019.1672792"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/09602011.2019.1667833"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2018.08.009"},{"key":"e_1_2_8_14_1","unstructured":"National Alzheimer's Coordinating Center. 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