{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:54:37Z","timestamp":1791219277803,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG054073"],"award-info":[{"award-number":["R01AG054073"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG058533"],"award-info":[{"award-number":["R01AG058533"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P41EB015922"],"award-info":[{"award-number":["P41EB015922"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19AG078109"],"award-info":[{"award-number":["U19AG078109"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54MD000214"],"award-info":[{"award-number":["U54MD000214"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30AG059298"],"award-info":[{"award-number":["P30AG059298"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>White matter hyperintensity volume (WMH), markers of cerebral small vessel disease, are\u00a0disproportionately prevalent among Black\/African American and Hispanic individuals. While cardiometabolic risk factors contribute to WMHs, their association across racial ethnic groups among females remains unclear. This study examines associations among cardiometabolic risk factors, blood pressure, and WMH\u00a0volume in non\u2010Hispanic White (NHW), non\u2010Hispanic Black (NHB), and Hispanic females.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Using the Health and Aging Brain Study Health Disparities (HABS\u2010HD) cross\u2010sectional visit 1 data (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a02209), we assessed cardiometabolic risk factors and blood pressure measures in relation to WMH\u00a0volume via multivariable linear regression models stratified by race\/ethnicity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Hypertension was associated with increased WMH volume in NHW females. Diabetes was a significant predictor in Hispanics. Systolic blood pressure and mean arterial pressure were associated with WMH\u00a0volume in NHB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Findings highlight racial differences in cardiometabolic contributions to WMH burden, emphasizing the need for tailored prevention strategies in racially and ethnically diverse female populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Overall, there was a main effect of hypertension; however, in stratified analyses hypertension was significantly was associated with greater white matter hyperintensity (WMH) burden in non\u2010Hispanic White females.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Non\u2010Hispanic Black females presented with a worse cardiometabolic profile, but this composite was not associated with WMH burden. There was a positive association with the risk composite in non\u2010Hispanic White and Hispanic females.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Systolic blood pressure and mean arterial pressure were associated with greater WMH in non\u2010Hispanic Black females, highlighting differential blood pressure contributions to WMH burden.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70327","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:15:12Z","timestamp":1748304912000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Racial ethnic variations in the cardiometabolic determinants and blood pressure of white matter hyperintensities among females\u2014The HABS\u2010HD Study"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6259-9456","authenticated-orcid":false,"given":"Cellas A.","family":"Hayes","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Population Health Stanford University School of Medicine Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle C.","family":"Odden","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health Stanford University School of Medicine Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul","family":"Vintimilla","sequence":"additional","affiliation":[{"name":"Institute for Translational Research University of North Texas Health Science Center Fort Worth Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Roland J.","family":"Thorpe","sequence":"additional","affiliation":[{"name":"Program for Research on Men's Health Johns Hopkins Center for Health Disparities Solutions Johns Hopkins Bloomberg School of Public Health Baltimore Maryland USA"},{"name":"Johns Hopkins Alzheimer's Disease Resource Center for Minority Aging Research Johns Hopkins Bloomberg School of Public Health Baltimore Maryland 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