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Here we investigate a new measure combining magnitude and extent\u2014Tau\u2010MaX\u2014as a marker of Alzheimer's disease (AD) severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      A total of 1077\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010flortaucipir positron emission tomography scans were analyzed using Gaussian mixture models to identify tau+ regions and quantify magnitude of accumulation. We assessed Tau\u2010MaX across the AD spectrum and compared associations of plasma biomarkers and cognition to global Tau\u2010MaX, extent, and magnitude.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Tau\u2010MaX dynamically captured an early shift in spatial spreading to later tau accumulation across the disease spectrum. Tau\u2010MaX had robust associations with plasma biomarkers and cross\u2010sectional and longitudinal cognition. Global Tau\u2010MaX was equivalent to or superior to magnitude or extent measures alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Tau\u2010MaX provides a region\u2010agnostic measure of global tau burden that can be used to track disease progression across the AD continuum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>We measured tau extent, magnitude, and a new combination of these metrics, Tau\u2010MaX.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Extent increases early in disease, while magnitude increases in later disease stages.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Tau\u2010MaX captures this shift and is closely associated with phosphorylated tau217 and cognition.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Global Tau\u2010MaX performed similarly to or better than meta\u2010region of interest tau magnitude or extent.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Tau\u2010MaX provides a region\u2010agnostic measure of tau burden to track progression.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70346","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T07:19:09Z","timestamp":1751613549000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Tau burden is best captured by magnitude and extent: Tau\u2010MaX as a measure of global tau"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2057-3976","authenticated-orcid":false,"given":"Christopher A.","family":"Brown","sequence":"first","affiliation":[{"name":"Department of Neurology University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandhitsu R.","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katheryn A. 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