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Dementia"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Monoclonal anti\u2010amyloid therapies are now accessible, but how these treatments influence changes within the brain is still not clear. We investigated overall and regional change in amyloid removal, glucose metabolism, and atrophy in trial participants with dominantly inherited Alzheimer's disease (DIAD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      In the DIAN\u2010TU\u2010001 trial, 92 carriers received gantenerumab or placebo and underwent serial neuroimaging assessments including [\n                      <jats:sup>11<\/jats:sup>\n                      C]\u2010Pittsburgh compound\u2010B (PiB) positron emission tomography (PET), [\n                      <jats:sup>18<\/jats:sup>\n                      F]\u2010fluoro\u20102\u2010deoxyglucose (FDG) PET, and magnetic resonance imaging (MRI).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Gantenerumab significantly reduced PiB\u2010PET uptake overall and in most regions and showed no changes in FDG\u2010PET or MRI measures. Drug effects were associated with baseline PiB\u2010PET uptake, and the largest effects occurred in medial regions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Treated DIAD participants, and especially those with higher amyloid burden, showed a decrease in PiB\u2010PET uptake, which was more pronounced in the basal ganglia and medial frontal structures. These results may inform patient response and future drug trial design.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Gantenerumab unevenly decreased A\u03b2 burden as measured by PiB\u2010PET across brain regions.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The strongest decrease in PiB\u2010PET uptake was in basal ganglia and medial frontal structures.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Variable drug effect on A\u03b2 was partly due to the amount of burden present before treatment.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>There was no regional effect on FDG\u2010PET metabolism or MRI volumetrics after 4 years.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70347","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T06:03:46Z","timestamp":1752559426000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Regional effects of gantenerumab on neuroimaging biomarkers in the DIAN\u2010TU\u2010001 trial"],"prefix":"10.1002","volume":"21","author":[{"given":"Austin","family":"McCullough","sequence":"first","affiliation":[{"name":"Washington University School of Medicine in Saint Louis  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles 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