{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T19:29:14Z","timestamp":1788895754769,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>Given the close interactions between the retina and the brain, retinal amyloid imaging may serve as a diagnostic and prognostic tool for Alzheimer's disease and related dementias. This retrospective study investigated multivariable associations between retinal perivascular amyloid and cognitive domains.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Integrated analysis of retinal perivascular amyloid imaging, neuropsychological assessment, and brain magnetic resonance imaging in adults with and without cognitive impairment (<jats:italic>N<\/jats:italic>\u00a0=\u00a026; mean age: 65\u00a0\u00b1\u00a07 years; 50% female). Correlations between perivascular amyloid plaque burden and cognitive domains were evaluated with linear regression and interactions with hippocampal volumetry were explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Higher perivascular and periarteriolar amyloid plaque count in the secondary small and tertiary branches were associated with poorer verbal and visual memory in this cohort (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.005\u20130.009). Higher perivascular amyloid burden interacted with hippocampal atrophy to worsen visual memory (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.033).<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Retinal perivascular amyloid may serve as a non\u2010invasive marker for cognitive impairment and may shed insight into pathological changes in the brain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>In vivo retinal perivascular amyloid plaque counts are associated with poorer memory.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Retinal perivascular amyloid interacted with hippocampal atrophy to worsen memory.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Retinal amyloid imaging is a potential biomarker for neurodegenerative diseases.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.70366","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T23:45:26Z","timestamp":1750203926000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Integrated analysis of in vivo retinal perivascular amyloid imaging and cognition"],"prefix":"10.1002","volume":"21","author":[{"given":"Mitzi","family":"Gonzales","sequence":"first","affiliation":[{"name":"Department of Neurology Cedars\u2010Sinai Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieu\u2010Trang","family":"Fuchs","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Maxine Dunitz Neurosurgical Institute, Cedars\u2010Sinai Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonah","family":"Doustar","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Maxine Dunitz Neurosurgical Institute, Cedars\u2010Sinai Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosef","family":"Koronyo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Maxine Dunitz Neurosurgical Institute, Cedars\u2010Sinai Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale S.","family":"Sherman","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine &amp; 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