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Positron emission tomography (PET)\u00a0scan revealed A+\/T+ positivity rates of\u00a015.8% in CU, 51.2%\u00a0in MCI, and 100% in Alzheimer's disease\u00a0dementia\u00a0(ADD). Plasma tau phosphorylated at threonine 181 (p\u2010tau181) level increased gradually\u00a0across the AD\u00a0continuum. Blood p\u2010tau181 and 18F\u2010Florzolotau PET showed comparable utility\u00a0for amyloid status\u00a0identification. In a subcohort of 251 amnestic MCI (aMCI) patients,\u00a0low A\u03b242\/A\u03b240 and elevated\u00a0p\u2010tau181 predicted 4.7\u2010year ADD risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>By offering an integrated framework, SMS will facilitate the exploration of AD pathogenesis and the understanding of cognitive disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>The SMS is an ongoing prospective cohort study based on a memory clinic in China.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The SMS has established a relatively large\u2010scale dataset that includes clinical data, biofluid markers, MRI and PET imaging, and novel biomarkers.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>By offering an integrated framework, SMS aims to facilitate the exploration of AD pathogenesis and deepen our understanding of cognitive disorders.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.70378","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T02:21:16Z","timestamp":1750904476000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical features, biomarker profiles, and neuroimaging characteristics in patients from memory clinic in china: The Shanghai Memory Study"],"prefix":"10.1002","volume":"21","author":[{"given":"Jie","family":"Wang","sequence":"first","affiliation":[{"name":"Department and Institute of Neurology Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxi","family":"Ma","sequence":"additional","affiliation":[{"name":"Department and Institute of Neurology Huashan Hospital Fudan University  Shanghai 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