{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:35:20Z","timestamp":1760056520308,"version":"build-2065373602"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009389","name":"Stiftelsen Promobilia","doi-asserted-by":"publisher","award":["21027","A23028"],"award-info":[{"award-number":["21027","A23028"]}],"id":[{"id":"10.13039\/100009389","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>Adults with Down syndrome (DS) are at a high risk for dementia, yet cognitive screening is complicated by premorbid intellectual disabilities. This study evaluated the feasibility of using eye\u2010tracking technology as a screening tool.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Ten adults with DS (five with dementia, five without) completed cognitive tasks while their eye movements were recorded. Feasibility was assessed through calibration success, gaze sample quality, and task completion.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Calibration was successful for most subjects (except one individual with dementia required five attempts and had low gaze sampling). Most subjects achieved 50%\u201388% gaze sample rates and completed testing with staff support. Subjects with dementia showed longer times to first fixation but similar fixation durations compared to those without dementia. Cognitive scores were lower in the dementia group but not significantly correlated with gaze quality.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Eye tracking may be a feasible method for cognitive screening in DS, but further validation is needed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Eye\u2010tracking may be a potential non\u2010verbal method for cognitive screening in individuals with DS.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Support from staff for engaging the subjects could be essential for maintaining attention on the computer screen.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.70385","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T01:56:13Z","timestamp":1750125373000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The feasibility of using eye\u2010tracking technology for cognitive screening in Down syndrome with dementia: A cross\u2010sectional case series"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5567-9431","authenticated-orcid":false,"given":"Helen","family":"Lindner","sequence":"first","affiliation":[{"name":"School of Health Sciences, Faculty of Medicine and Health \u00d6rebro University  \u00d6rebro Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lotfi B.","family":"Merabet","sequence":"additional","affiliation":[{"name":"The Laboratory for Visual Neuroplasticity, Department of Ophthalmology Massachusetts Eye and Ear, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars\u2010Olov","family":"Lundqvist","sequence":"additional","affiliation":[{"name":"University Health Care Research Center, Faculty of Medicine and Health \u00d6rebro University  \u00d6rebro Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4172\/2161-0460.S7-001"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2788.1999.043005400.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/13607860310001594682"},{"key":"e_1_2_7_5_1","unstructured":"KarlssonB BjorkmanM.Early signs survey instrument. 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