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However, promising biomarkers of epileptogenicity, such as high\u2010frequency oscillations (HFOs\u00a0&gt;250\u00a0Hz), have not been studied. This study is the first to use wideband polysomnography in DS to investigate if HFOs occurred and preceded AD dementia and LOMEDS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Wideband (0.1 to 500\u00a0Hz, 2048\u00a0Hz) polysomnography was performed using the international 10\u201020 system. HFOs were automatically detected during slow\u2010wave sleep, followed by manual review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Fourteen individuals with DS and five age\u2010matched euploid controls were studied, with all DS cases showing HFOs. HFOs emerged before AD dementia and LOMEDS and showed hemispheric lateralization in asymptomatic but not symptomatic AD dementia cases. A trend toward increasing HFO rates with age in DS warrants further confirmation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>HFOs are promising biomarkers that may predict symptomatic AD dementia in adults with DS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Wideband polysomnography reveals a new electrical abnormality in DS.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>HFOs precede AD dementia in DS.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The occurrence of HFOs in DS is independent of an epilepsy diagnosis.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>HFOs showed hemispheric lateralization in asymptomatic DS cases.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>A trend of increased HFO rate with advancing age warrants further investigation.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70386","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T11:00:33Z","timestamp":1752231633000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["High\u2010frequency oscillations &gt;250\u00a0Hz in people with Down syndrome and associated Alzheimer's disease dementia"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3712-5993","authenticated-orcid":false,"given":"Christos Panagiotis","family":"Lisgaras","sequence":"first","affiliation":[{"name":"Department of Psychiatry New York University Grossman School of Medicine  New York New York USA"},{"name":"The Nathan S. 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