{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:05:54Z","timestamp":1790165154938,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2018\u201002532"],"award-info":[{"award-number":["2018\u201002532"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2017\u201000915"],"award-info":[{"award-number":["2017\u201000915"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["681712"],"award-info":[{"award-number":["681712"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30AG066508"],"award-info":[{"award-number":["P30AG066508"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P50AG047270"],"award-info":[{"award-number":["P50AG047270"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG052560"],"award-info":[{"award-number":["R01AG052560"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG062276"],"award-info":[{"award-number":["R01AG062276"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003792","name":"Hj\u00e4rnfonden","doi-asserted-by":"publisher","award":["FO2019\u20100228"],"award-info":[{"award-number":["FO2019\u20100228"]}],"id":[{"id":"10.13039\/501100003792","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Positron emission tomography (PET) imaging with ligands for synaptic vesicle glycoprotein 2A (SV2A) has emerged as a promising methodology for measuring synaptic density in Alzheimer's disease (AD). We investigated the relationship between SV2A PET and CSF synaptic protein changes of AD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHOD<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010one participants with early AD and seven cognitively normal (CN) individuals underwent [\n                      <jats:sup>11<\/jats:sup>\n                      C]UCB\u2010J PET. We used mass spectrometry to measure a panel of synaptic proteins in cerebrospinal fluid (CSF).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>In the AD group, higher levels of syntaxin\u20107 and PEBP\u20101 were associated with lower global synaptic density. In the total sample, lower global synaptic density was associated with higher levels of AP2B1, neurogranin, \u03b3\u2010synuclein, GDI\u20101, PEBP\u20101, syntaxin\u20101B, and syntaxin\u20107 but not with the levels of the neuronal pentraxins or 14\u20103\u20103 zeta\/delta.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      Reductions of synaptic density found in AD compared to CN participants using [\n                      <jats:sup>11<\/jats:sup>\n                      C]UCB\u2010J PET were observed to be associated with CSF biomarker levels of synaptic proteins.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>A panel of synaptic proteins was quantified in the CSF using mass spectrometry.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            SV2A ([\n                            <jats:sup>11<\/jats:sup>\n                            C]UCB\u2010J) PET was used to quantify synaptic density.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Reductions of synaptic density were associated with CSF synaptic biomarker levels.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70403","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T04:52:23Z","timestamp":1752209543000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Associations between fluid biomarkers and PET imaging ([11C]UCB\u2010J) of synaptic pathology in Alzheimer's disease"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2856-6060","authenticated-orcid":false,"given":"Johanna","family":"Nilsson","sequence":"first","affiliation":[{"name":"Institute of Neuroscience and Physiology the Sahlgrenska Academy at the University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam P.","family":"Mecca","sequence":"additional","affiliation":[{"name":"Yale Alzheimer's Disease Research Unit, Yale School of Medicine  New Haven USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Ashton","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and Physiology the Sahlgrenska Academy at the University of Gothenburg  Gothenburg Sweden"},{"name":"Wallenberg Centre for Molecular and Transla Medicine University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Old Age Psychiatry Maurice Wohl Clinical Neuroscience Institute, King's College London  London UK"},{"name":"NIHR Biomedical Research Centre for Mental Health &amp; Biomedical Research Unit for Dementia at South London &amp; Maudsley NHS Foundation  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaheh","family":"Salardini","sequence":"additional","affiliation":[{"name":"Yale Alzheimer's Disease Research Unit, Yale School of Medicine  New Haven USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan S.","family":"O'Dell","sequence":"additional","affiliation":[{"name":"Yale Alzheimer's Disease Research Unit, Yale School of Medicine  New Haven USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard E.","family":"Carson","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging Yale University School of Medicine  New Haven USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea L.","family":"Benedet","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and Physiology the Sahlgrenska Academy at the University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Neurology &amp; Neurosurgery McGill University Montr\u00e9al  Rue University Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaj","family":"Blennow","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and Physiology the Sahlgrenska Academy at the University of Gothenburg  Gothenburg Sweden"},{"name":"Clinical Neurochemistry Laboratory Sahlgrenska University Hospital Biskopsbogatan  M\u00f6lndal Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and Physiology the Sahlgrenska Academy at the University of Gothenburg  Gothenburg Sweden"},{"name":"Clinical Neurochemistry Laboratory Sahlgrenska University Hospital Biskopsbogatan  M\u00f6lndal Sweden"},{"name":"UK Dementia Research Institute at UCL  London UK"},{"name":"Department of Neurodegenerative Disease UCL Institute of Neurology  London UK"},{"name":"Hong Kong Center for Neurodegenerative Diseases  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher H.","family":"van Dyck","sequence":"additional","affiliation":[{"name":"Yale Alzheimer's Disease Research Unit, Yale School of Medicine  New Haven USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Brinkmalm","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and Physiology the Sahlgrenska Academy at the University of Gothenburg  Gothenburg Sweden"},{"name":"Clinical Neurochemistry Laboratory Sahlgrenska University Hospital Biskopsbogatan  M\u00f6lndal Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1177271920950319"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410300410"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2683(19990301)20:3<431::AID-ELPS431>3.0.CO;2-2"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-019-01326-z"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12131"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-022-01021-8"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012853"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000201417"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12809"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29287"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-022-01042-3"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.1836"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12097"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2021.11.004"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X211004312"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-020-00742-y"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28617"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-95499-1"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25682"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012969"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2019.02.001"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12582"},{"issue":"1","key":"e_1_2_11_26_1","article-title":"Cerebrospinal fluid biomarker panel for synaptic dysfunction in Alzheimer's disease. Alzheimer's & Dementia: diagnosis","volume":"13","author":"Nilsson J","year":"2021","journal-title":"Assess Dis Monit."},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2001-2-11-reviews3012"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2021.105360"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.9.3079-3085.2000"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20215367"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-021-02411-2"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2019.11.002"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201400178"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2016.07.148"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.15095.1"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2020.03.013"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12353"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.70403","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.70403","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.70403","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:58:10Z","timestamp":1784303890000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.70403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/alz.70403"],"URL":"https:\/\/doi.org\/10.1002\/alz.70403","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2025.03.31.646290","asserted-by":"object"}]},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-04-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70403"}}