{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:14:04Z","timestamp":1792174444296,"version":"4.4.0"},"reference-count":183,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AG061190\u201001"],"award-info":[{"award-number":["R01 AG061190\u201001"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01\u2010AG062276"],"award-info":[{"award-number":["R01\u2010AG062276"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30\u2010AG066508"],"award-info":[{"award-number":["P30\u2010AG066508"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AG061190"],"award-info":[{"award-number":["R01 AG061190"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21 AG079145\u201001"],"award-info":[{"award-number":["R21 AG079145\u201001"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["KL2 TR001862"],"award-info":[{"award-number":["KL2 TR001862"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012513","name":"Coins for Alzheimer's Research Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012513","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Alzheimer's disease (AD) research is a large and burgeoning field, where varied methodological approaches are providing multifaceted, but sometimes contradictory, views on the etiology and progression of pathology. The current review aims to summarize and integrate these findings to provide greater coherence to an increasingly splintered field. We provide an overview of the findings from each subfield (neuropathology, positron emission tomography imaging, fluid biomarkers, genetics, transcriptomics\/proteomics), highlighting the strengths and weaknesses of each approach and, where possible, trying to resolve discrepancies between subfields. In particular, we address arguments about whether amyloid versus tau initiates pathology, and integrate nanoscale data from aging macaques to improve clarity regarding the earliest pathological stages, as initial phosphorylation events can be lost\n                      <jats:italic>post mortem<\/jats:italic>\n                      in human tissue. We find that A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      , phosphorylated tau, and inflammation\/excessive calcium can all interact in feedforward cycles to drive AD pathology. Increasing cohesion across subdisciplines will strengthen our understanding of this devastating disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>AD research is an expansive field, where subfields often diverge.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The current review integrates across approaches to give a more cohesive view.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Many methods cannot detect the earliest changes in brain.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The new fluid biomarker pT217Tau shows that soluble tau pathology begins early.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Relating amyloid\/tau pathologies to inflammation is key for understanding sporadic AD.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70404","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T11:01:05Z","timestamp":1754478065000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["An integrated view of the relationships between amyloid, tau, and inflammatory pathophysiology in Alzheimer's disease"],"prefix":"10.1002","volume":"21","author":[{"given":"Amy F. T.","family":"Arnsten","sequence":"first","affiliation":[{"name":"Department of Neuroscience Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Del Tredici","sequence":"additional","affiliation":[{"name":"Clinical Neuroanatomy\/Department of Neurology Center for Biomedical Research University of Ulm  Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas R.","family":"Barth\u00e9lemy","sequence":"additional","affiliation":[{"name":"Department of Neurology Washington University in St. Louis  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Gabitto","sequence":"additional","affiliation":[{"name":"Allen Institute for Brain Science  Seattle Washington USA"},{"name":"Department of Statistics University of Washington Northeast Stevens Way  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher H.","family":"van Dyck","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Yale School of Medicine  New Haven Connecticut USA"},{"name":"Department of Psychiatry Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Lein","sequence":"additional","affiliation":[{"name":"Allen Institute for Brain Science  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiko","family":"Braak","sequence":"additional","affiliation":[{"name":"Clinical Neuroanatomy\/Department of Neurology Center for Biomedical Research University of Ulm  Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dibyadeep","family":"Datta","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.10.007"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-36374-4"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cm.21820"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.10.029"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cm.21812"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2015.06.002"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.9b11720"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.13.4913"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200420640"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-023-03434-4"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1042\/EBC20210025"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.11.005"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90264-X"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep15709"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2008.05300.x"},{"key":"e_1_2_10_17_1","first-page":"10","article-title":"Postmortem changes in brain cell structure: a review","volume":"4","author":"Krassner MM","year":"2023","journal-title":"Free Neuropathol"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww230"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13737"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-02869-z"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2023.04.020"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-025-02862-x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1212100110"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12321"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-0914-2"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2168"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-16-06142.1997"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-1-8"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.06.036"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.12-02-00376.1992"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(93)90009-B"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2024.1112"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10138"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.06.005"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0503689102"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2017.08.003"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201606210"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-023-02679-6"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2007.04627.x"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14477"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-013-1153-2"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv236"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00308809"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.12.1791"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.77"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2008.05.002"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108420"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M500997200"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R109.080895"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4367-12.2013"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.072033799"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2007.00275.x"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858407299730"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13065"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200706171"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2010.10.005"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-187740"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e318232a379"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12192"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhy152"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00293315"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajp.23254"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.09.001"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(86)90288-0"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(92)90820-W"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00304639"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.12.006"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)00384-3"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-002-0528-6"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64538-5"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-01-00186.1996"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21029"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20202717"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410270502"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2023.3530"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2022.05.028"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.3.631"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(99)00063-9"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000063311.58879.01"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e31825018f7"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlw026"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6474172"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.07-06-01799.1987"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/1.1.103"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(97)00056-0"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(91)90096-U"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01273323"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.10.034"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-011-0865-4"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12558"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12325"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1997.6433"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12649"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-014-1349-0"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlaa153"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-015-1390-7"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-240483"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410200406"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-021-02294-3"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03911-7"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2025.1549770"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12481"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-018-1855-6"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000129697.01779.0A"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14165"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.0528"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.ado8076"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-022-00204-0"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-023-01237-2"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2305032"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12748"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.119.230458"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1990.00530070043010"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12880-024-01256-x"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-018-0114-z"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-19387-x"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-69065-0"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12097"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2021.11.004"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12582"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-020-00742-y"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000596"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12580"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212948"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.13239"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-022-02467-8"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02318-3"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8346443"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-021-03986-5"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043754"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.01.045"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.09.063"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.57354"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201606370"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.05.003"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.73021"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11243994"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.107719"},{"key":"e_1_2_10_139_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.3049"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2024.1443865"},{"key":"e_1_2_10_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-40208-x"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-024-01774-5"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1195-2"},{"key":"e_1_2_10_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.08.039"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41597-021-01090-8"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-00764-7"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-023-01356-x"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2022.903175"},{"key":"e_1_2_10_149_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-021-00071-1"},{"key":"e_1_2_10_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2022.06.021"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-025-00823-3"},{"key":"e_1_2_10_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2021.109095"},{"key":"e_1_2_10_153_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13784"},{"key":"e_1_2_10_154_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-50486-8"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-021-00999-y"},{"key":"e_1_2_10_156_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07871-6"},{"key":"e_1_2_10_157_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abq5923"},{"key":"e_1_2_10_158_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-024-01737-w"},{"key":"e_1_2_10_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.08.005"},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-52297-3"},{"key":"e_1_2_10_161_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1101"},{"key":"e_1_2_10_162_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-024-00731-y"},{"key":"e_1_2_10_163_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.81"},{"key":"e_1_2_10_164_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-023-12148-5"},{"key":"e_1_2_10_165_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34129-4"},{"key":"e_1_2_10_166_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-024-00599-y"},{"key":"e_1_2_10_167_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02443-z"},{"key":"e_1_2_10_168_1","doi-asserted-by":"publisher","DOI":"10.18103\/mra.v11i2.3487"},{"key":"e_1_2_10_169_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12431"},{"key":"e_1_2_10_170_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-017-1733-7"},{"key":"e_1_2_10_171_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.3114pe10"},{"key":"e_1_2_10_172_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70086"},{"key":"e_1_2_10_173_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.710579"},{"key":"e_1_2_10_174_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70062"},{"key":"e_1_2_10_175_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.340409"},{"key":"e_1_2_10_176_1","first-page":"S65","article-title":"Top\u2010line results from TANGO, a phase 2 study of gosuranemab in participants with mild cognitive impairment due to Alzheimer's disease and mild Alzheimer's disease","volume":"8","author":"Shulman M","year":"2021","journal-title":"J Prev Alzheimers Dis"},{"key":"e_1_2_10_177_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-020-0884-2"},{"key":"e_1_2_10_178_1","doi-asserted-by":"publisher","DOI":"10.1080\/13550280290100978"},{"key":"e_1_2_10_179_1","doi-asserted-by":"publisher","DOI":"10.3390\/cimb44120421"},{"key":"e_1_2_10_180_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.15540"},{"key":"e_1_2_10_181_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.970925"},{"key":"e_1_2_10_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2024.109952"},{"key":"e_1_2_10_183_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2025.0360"},{"key":"e_1_2_10_184_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-05165-3"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.70404","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T20:34:33Z","timestamp":1759955673000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.70404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":183,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1002\/alz.70404"],"URL":"https:\/\/doi.org\/10.1002\/alz.70404","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"2025-03-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70404"}}