{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:48:26Z","timestamp":1789015706651,"version":"build-2803163510"},"reference-count":67,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["AACSF\u201022\u2010924470"],"award-info":[{"award-number":["AACSF\u201022\u2010924470"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Receiving an Alzheimer's disease (AD) diagnosis can be a distressing experience, for both the individual with the condition and the family. This cross\u2010sectional study explored whether the disclosure of AD diagnosis generated post\u2010traumatic stress symptoms (PTSSs) in caregivers and how this affected their psychological well\u2010being.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Seventy\u2010nine caregivers completed the Impact of Event Scale to assess any PTSSs related to the memory of AD disclosure and clinical scales to assess current psychological distress.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>After a mean of 3 years, 46% of caregivers showed moderate\u2010to\u2010severe PTSS (mean\u00a0\u00b1\u00a0SD\u00a0=\u00a035.4\u00a0\u00b1\u00a06.8) related to the memory of AD disclosure. Compared to caregivers with subclinical\/mild PTSSs, they reported significantly higher levels of burden, anxiety, and depressive symptoms, mainly related to intrusive thoughts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Diagnosis disclosure is a watershed point in caregivers\u2019 career and might have a long\u2010term effect on their mental health. Effective communication strategies should be developed to mitigate its stressful impact.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>TRIAL REGISTRATION<\/jats:title>\n                    <jats:p>Registered in ClinicalTrials.gov: NCT05780476.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>The AD diagnosis disclosure could lead to developing PTSSs.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Higher PTSSs were associated with greater caregivers\u2019 psychological distress.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>PTSSs could foster long\u2010term negative psychological vulnerability.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70412","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T06:11:24Z","timestamp":1757052684000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The psychological impact of the disclosure of the diagnosis of Alzheimer's disease on informal caregivers"],"prefix":"10.1002","volume":"21","author":[{"given":"Claudio","family":"Singh Solorzano","sequence":"first","affiliation":[{"name":"Laboratory of Alzheimer's Neuroimaging and Epidemiology IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli  Brescia 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