{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:55:50Z","timestamp":1792518950196,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Alzheimer's disease and other dementias (ADOD) are a growing public health concern in Japan. This study examines historical ADOD burden trends, identifies contributing risk factors, and forecasts future projections using time\u2010series modeling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>This study uses the Global Burden of Disease (GBD) study 2021 data to analyze ADOD trends in Japan, and assess incidence, mortality, and Disability\u2010adjusted life years (DALYs). Regression analysis identifies risk factors, and an Autoregressive Integrated Moving Average (ARIMA) model is employed to forecasts the burden from 2021 to 2030.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>ADOD cases have steadily increased, with projections indicating continued growth by 2030. Aging and life expectancy are major contributors, with urban areas like Kant\u014d and Kansai region experiencing higher prevalence than T\u014dhoku and Ky\u016bsh\u016b. High fasting plasma glucose, obesity, and smoking are significant modifiable risk factors. The ARIMA model forecasts an ongoing upward trend, highlighting a rising public health challenge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Targeted policies, early interventions, and equitable health care access are vital to mitigating Japan's growing ADOD burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Alzheimer's disease and other dementias (ADOD) are rising in Japan due to an aging population.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Key risk factors include high fasting plasma glucose, obesity, and smoking.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Kant\u014d and Kansai region have higher ADOD prevalence than other region<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>ARIMA modeling predicts a continuous increase in ADOD cases through 2030.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Targeted health care policies and preventive measures are crucial to mitigate the burden.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70444","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T13:46:18Z","timestamp":1752068778000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Alzheimer's disease and dementia in Japan: Epidemiological trends, regional disparities, and future projections"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6539-4280","authenticated-orcid":false,"given":"Deepak Kumar","family":"Behera","sequence":"first","affiliation":[{"name":"Economics and Finance Department, The Business School RMIT University Vietnam  Ho Chi Minh Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7505-5271","authenticated-orcid":false,"given":"Dil B.","family":"Rahut","sequence":"additional","affiliation":[{"name":"Asian Development Bank Institute (ADBI)  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snehasish","family":"Tripathy","sequence":"additional","affiliation":[{"name":"Department of Dental Research Cell, Dr. D. Y. Patil Dental College and Hospital Dr. D. Y. Patil Vidyapeeth  Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2021.05.040"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahr.2021.100013"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.937486"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.50786.1"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20102667(21)00249\u20108"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibra.12181"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214\u2010109X(24)00264\u2010X"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/13696998.2021.1877149"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877\u2010016\u20100298\u2010y"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cccb.2023.100193"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.35772\/ghm.2023.01047"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877\u2010021\u201002540\u2010z"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/gbx147"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwy234"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14254"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13690\u2010022\u201000962\u20108"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2024.47"},{"key":"e_1_2_9_19_1","unstructured":"Global Burden of Disease Collaborative Network.Global Burden of Disease Study 2021 (GBD 2021) Results. 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