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We performed confounder\u2010adjusted mixed linear regression between infectious serologies and longitudinal cognitive performance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      CMV and HSV\u20102 serologies were associated with impaired executive function, whereas\n                      <jats:italic>C. pneumoniae<\/jats:italic>\n                      serology was associated with impaired performance on language testing. In univariate Cox proportional hazard models, CMV serologies were associated with incident cognitive impairment and dementia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>CMV seropositivity may accelerate domain\u2010specific cognitive worsening and could confer increased risk for cognitive impairment and dementia, warranting further evaluation in observational and experimental datasets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Infectious exposures may contribute to neurodegeneration and risk of cognitive impairment.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Cytomegalovirus (CMV) and herpes simplex virus 2 exposure were associated with impaired executive function.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            <jats:italic>Chlamydia pneumoniae<\/jats:italic>\n                            was associated with decreased performance on language testing.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>CMV may be associated with incident cognitive impairment and dementia.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70457","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T18:20:37Z","timestamp":1761070837000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The association of common infectious exposures with cognitive performance in community\u2010dwelling older adults"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2231-2454","authenticated-orcid":false,"given":"Jackson A.","family":"Roberts","sequence":"first","affiliation":[{"name":"Department of Neurology Vagelos College of Physicians and Surgeons Columbia University  New York New York USA"},{"name":"Department of Neurology Massachusetts General Brigham  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell S. 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