{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:20:56Z","timestamp":1793298056918,"version":"4.5.0"},"reference-count":56,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P01\u2010AG066597 P30\u2010AG072979 R01\u2010AG087258"],"award-info":[{"award-number":["P01\u2010AG066597 P30\u2010AG072979 R01\u2010AG087258"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>In clinically and racially diverse training and test sets, we evaluated and validated Alzheimer's disease (AD) plasma biomarkers: phosphorylated tau\u2010217 (p\u2010tau217), amyloid beta 1\u201042\/1\u201040 (A\u03b242\/A\u03b240), and p\u2010tau217\/A\u03b242.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Inclusion criteria were available plasma, race (people who self\u2010identified as Black\/African American [pBlack] or White [pWhite]), cognitive status (normal, mild cognitive impairment [MCI], dementia), and\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010florbetaben or\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010florbetapir positron emission tomography (PET) data. In the training set (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0289; 28% pBlack), we used receiver\u2010operating characteristic (ROC) analysis to calculate two cut points (0.95 sensitivity and specificity) to detect amyloid PET positivity. Cut points were validated in an independent test set (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0846; 12% pBlack).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      In the test set, plasma p\u2010tau217\/A\u03b242 had the highest accuracy (pBlack: 0.88, pWhite: 0.91) and lowest proportion of intermediate classifications (\u22640.16), with no classification difference by race (odds ratio [OR]\u00a0=\u00a01.45, 95% confidence interval [CI]\u00a0=\u00a00.66\u20132.95,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.33). False negatives were more likely to be cognitively normal (vs\u00a0mild cognitive impairment [MCI]; OR\u00a0=\u00a07.79, 95% CI\u00a0=\u00a02.33\u201340.81,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a05.1e\u201005) than correct classifications.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Plasma p\u2010tau217\/A\u03b242 had high accuracy to detect AD, with comparable performance across race.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>\n                            We tested plasma phosphorylated tau\u2010217 (p\u2010tau217)\/amyloid beta (A\u03b2)\n                            <jats:sub>42<\/jats:sub>\n                            , p\u2010tau217, and A\u03b242\/A\u03b240 in diverse training and test sets.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>In models, race \u00d7 amyloid PET interactions were not significant.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Plasma p\u2010tau217\/A\u03b242 had the highest accuracy in people who self\u2010identified as Black\/African American (pBlack; 0.88) and people who self\u2010identified as White (pWhite; 0.91).<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Plasma p\u2010tau217\/A\u03b242 had the lowest proportion of intermediate cases (range\u00a0=\u00a00.09\u20130.16).<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>False negatives were more likely to have normal cognition, female sex, and high body mass index.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70469","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T11:28:07Z","timestamp":1755084487000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Comparison of plasma p\u2010tau217\/A\u03b242, p\u2010tau217, and A\u03b242\/A\u03b240 biomarkers by race to detect Alzheimer's disease"],"prefix":"10.1002","volume":"21","author":[{"given":"Katheryn A. Q.","family":"Cousins","sequence":"first","affiliation":[{"name":"Department of Neurology Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Korecka","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amberley","family":"Vulaj","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania 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Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Landau","sequence":"additional","affiliation":[{"name":"Neuroscience Department University of California  Berkeley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozioma C.","family":"Okonkwo","sequence":"additional","affiliation":[{"name":"Department of Medicine and the Wisconsin Alzheimer's Disease Research Center University of Wisconsin  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica Rivera","family":"Mindt","sequence":"additional","affiliation":[{"name":"Department of Psychology Fordham University  New York New York USA"},{"name":"Department of Neurology Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Weiner","sequence":"additional","affiliation":[{"name":"Northern California Institute for Research &amp; Education  San Francisco California USA"},{"name":"Departments of Radiology Medicine, Psychiatry &amp; Neurology University of California San Francisco  San Francisco California USA"},{"name":"Center for Imaging of Neurodegenerative Diseases San Francisco Veterans Administration Medical Center San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Irwin","sequence":"additional","affiliation":[{"name":"Department of Neurology Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Wolk","sequence":"additional","affiliation":[{"name":"Department of Neurology Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie M.","family":"Shaw","sequence":"additional","affiliation":[{"name":"Department of 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