{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T10:31:51Z","timestamp":1793788311687,"version":"4.6.1"},"reference-count":79,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G0F8516N"],"award-info":[{"award-number":["G0F8516N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G065721N"],"award-info":[{"award-number":["G065721N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G024925N [DRT]"],"award-info":[{"award-number":["G024925N [DRT]"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["1225725N [SOT]"],"award-info":[{"award-number":["1225725N [SOT]"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["22\u2010AAIIA\u2010963171 [DRT]"],"award-info":[{"award-number":["22\u2010AAIIA\u2010963171 [DRT]"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["AARF\u201024\u20101300693 [SOT]"],"award-info":[{"award-number":["AARF\u201024\u20101300693 [SOT]"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TH\u2010624\u20104\u20101"],"award-info":[{"award-number":["TH\u2010624\u20104\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TH\u2010624\u20104\u20102"],"award-info":[{"award-number":["TH\u2010624\u20104\u20102"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TH\u2010624\u20106\u20101 [DRT]"],"award-info":[{"award-number":["TH\u2010624\u20106\u20101 [DRT]"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1279 [MO]"],"award-info":[{"award-number":["SFB1279 [MO]"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010146","name":"Alzheimer Forschung Initiative","doi-asserted-by":"publisher","award":["#10810"],"award-info":[{"award-number":["#10810"]}],"id":[{"id":"10.13039\/100010146","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010146","name":"Alzheimer Forschung Initiative","doi-asserted-by":"publisher","award":["#13803 [DRT]"],"award-info":[{"award-number":["#13803 [DRT]"]}],"id":[{"id":"10.13039\/100010146","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006312","name":"BrightFocus Foundation","doi-asserted-by":"publisher","award":["A2022019F[SOT]"],"award-info":[{"award-number":["A2022019F[SOT]"]}],"id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009281","name":"Fondation Thierry Latran","doi-asserted-by":"publisher","award":["D.2468"],"award-info":[{"award-number":["D.2468"]}],"id":[{"id":"10.13039\/100009281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009281","name":"Fondation Thierry Latran","doi-asserted-by":"publisher","award":["D.2468 [MO]"],"award-info":[{"award-number":["D.2468 [MO]"]}],"id":[{"id":"10.13039\/100009281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022576","name":"BonaRes","doi-asserted-by":"publisher","award":["01GI1007A [MO]"],"award-info":[{"award-number":["01GI1007A [MO]"]}],"id":[{"id":"10.13039\/501100022576","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>In neurodegenerative dementias, the co\u2010occurrence and interaction of amyloid \u03b2\u00a0peptide\u00a0(A\u03b2), tau pathology, and other pathological lesions confound their individual contributions to neurodegeneration and their modulation by risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      We analyzed 480\n                      <jats:italic>post mortem<\/jats:italic>\n                      human brains (ages 50\u201399) using regression and structural equation models to assess the relationships among A\u03b2, tau, limbic\u2010predominant age\u2010related TDP\u201043 encephalopathy neuropathological changes (LATE\u2010NC), \u03b1\u2010synuclein, other age\u2010related lesions, and apolipoprotein E (\n                      <jats:italic>APOE<\/jats:italic>\n                      ) \u03b54, as well as their effects on CA1 neuronal density, brain weight, and cognitive status.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      A\u03b2, tau, LATE\u2010NC, and amygdala\u2010predominant \u03b1\u2010synuclein pathology were mutually interdependent. Tau was the strongest predictor of global neurodegeneration, while LATE\u2010NC primarily, but not exclusively, affected hippocampal neuron loss. Small vessel disease correlated with both LATE\u2010NC and \u03b1\u2010synuclein, while\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 was mainly associated with extracellular\u00a0parenchymal and capillary A\u03b2 pathology.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Although Alzheimer's disease pathology plays a central role in brain degeneration, coexisting pathologies can both exacerbate and independently contribute to it. These factors should be considered in patient stratification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>\n                            In aging individuals, amyloid \u03b2\n                            <jats:styled-content>peptide\u00a0<\/jats:styled-content>\n                            (A\u03b2), tau pathology, limbic\u2010predominant age\u2010related TDP\u201043 encephalopathy neuropathological changes (LATE\u2010NC), and amygdala\u2010predominant \u03b1\u2010synuclein pathology were interrelated but contributed independently to neurodegeneration.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            LATE\u2010NC was the\n                            <jats:styled-content>strongest<\/jats:styled-content>\n                            \u00a0driver of CA1 neuronal loss, while tau burden was the strongest predictor of global brain degeneration.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Apolipoprotein E \u03b54 was associated with both extracellular and capillary A\u03b2 deposits, but not with tau burden.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Temporal lobe small vessel disease was associated with both LATE\u2010NC and amygdala\u2010predominant \u03b1\u2010synuclein pathology.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Neural network models can reliably identify hippocampal pyramidal neurons on hematoxylin\u2010stained histological slides.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70483","type":"journal-article","created":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T03:44:06Z","timestamp":1752637446000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Alzheimer's disease and its co\u2010pathologies: Implications for hippocampal degeneration, cognitive decline, and the role of\n                    <i>APOE<\/i>\n                    \u03b54"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7571-5420","authenticated-orcid":false,"given":"Klara","family":"Gawor","sequence":"first","affiliation":[{"name":"Department of Imaging and Pathology Laboratory of Neuropathology, KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0918-7890","authenticated-orcid":false,"given":"Sam","family":"Verrept","sequence":"additional","affiliation":[{"name":"Department of Imaging and Pathology Laboratory of Neuropathology, KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2639-9964","authenticated-orcid":false,"given":"Geethika","family":"Arekatla","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Laboratory of Neurobiology, KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8000-8023","authenticated-orcid":false,"given":"David","family":"Wouters","sequence":"additional","affiliation":[{"name":"Department of Human Genetics Laboratory of Multi\u2010omic Integrative Bioinformatics, KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4310-0445","authenticated-orcid":false,"given":"Alicja","family":"Ronisz","sequence":"additional","affiliation":[{"name":"Department of Imaging and Pathology Laboratory of Neuropathology, KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz","family":"Hecht","sequence":"additional","affiliation":[{"name":"Laboratory of Neuropathology, Institute of Pathology Ulm University  Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7373-2099","authenticated-orcid":false,"given":"Celeste","family":"Laureyssen","sequence":"additional","affiliation":[{"name":"Complex Genetics of\u00a0Alzheimer's Disease Group VIB Center for Molecular Neurology, VIB  Antwerp Belgium"},{"name":"Department of\u00a0Biomedical Sciences University of Antwerp  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena Ver","family":"Donck","sequence":"additional","affiliation":[{"name":"Department of Imaging and Pathology Laboratory of Neuropathology, KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5887-6844","authenticated-orcid":false,"given":"Bas","family":"Lahaije","sequence":"additional","affiliation":[{"name":"Department of Imaging and Pathology Laboratory of Neuropathology, KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Ospitalieri","sequence":"additional","affiliation":[{"name":"Department of Imaging and Pathology Laboratory of Neuropathology, KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Vandenbulcke","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Laboratory for Translational Neuropsychiatry, KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Otto","sequence":"additional","affiliation":[{"name":"Department of Neurology Ulm University  Ulm Germany"},{"name":"Department of Neurology University of Halle  Halle Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8614-2223","authenticated-orcid":false,"given":"Christine A. F.","family":"von Arnim","sequence":"additional","affiliation":[{"name":"Department of Neurology Ulm University  Ulm Germany"},{"name":"Department of Geriatrics University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estifanos","family":"Ghebremedhin","sequence":"additional","affiliation":[{"name":"Institute of Anatomy Johann Wolfgang Goethe University  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3102-6778","authenticated-orcid":false,"given":"Bernard","family":"Hanseeuw","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience, UCLouvain  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6237-2502","authenticated-orcid":false,"given":"Rik","family":"Vandenberghe","sequence":"additional","affiliation":[{"name":"Department of Neurology UZ Leuven  Leuven Belgium"},{"name":"Department of Neurosciences Laboratory for Cognitive Neurology, KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2640-181X","authenticated-orcid":false,"given":"Matthew","family":"Blaschko","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering Processing Speech and Images, KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8247-4020","authenticated-orcid":false,"given":"Alejandro","family":"Sifrim","sequence":"additional","affiliation":[{"name":"Department of Human Genetics Laboratory of Multi\u2010omic Integrative Bioinformatics, KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0283-2332","authenticated-orcid":false,"given":"Kristel","family":"Sleegers","sequence":"additional","affiliation":[{"name":"Complex Genetics of\u00a0Alzheimer's Disease Group VIB Center for Molecular Neurology, VIB  Antwerp Belgium"},{"name":"Department of\u00a0Biomedical Sciences University of Antwerp  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1036-1075","authenticated-orcid":false,"given":"Dietmar Rudolf","family":"Thal","sequence":"additional","affiliation":[{"name":"Department of Imaging and Pathology Laboratory of Neuropathology, KU Leuven  Leuven Belgium"},{"name":"Department of Pathology UZ Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5253-0730","authenticated-orcid":false,"given":"Sandra O.","family":"Tom\u00e9","sequence":"additional","affiliation":[{"name":"Department of Imaging and Pathology Laboratory of Neuropathology, KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010011\u20100910\u20103"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00308809"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.58.12.1791"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666\u20107568(23)00019\u20103"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000508625"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa438"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2011.09.005"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.49.3.786"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz099"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010015\u20101526\u20109"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010014\u20101269\u2010z"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010019\u201002071\u20103"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.jnen.0000225908.90052.07"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1062097"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12427"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcae442"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010021\u201002295\u20102"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.09.048"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2021.166953"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010017\u20101681\u20102"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u20102011\u2010110830"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm305"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010023\u201002606\u20109"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478\u2010022\u201001432\u20106"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478\u2010014\u20100131\u20109"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010220624"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010001\u20100471\u2010y"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.031551"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2006.06.008"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582\u2010024\u201000988\u20102"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004606"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010024\u201001939\u20109"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010024\u201002815\u2010w"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.104784"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.140.6.566"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010783.pub2"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.JGP.0000192478.82189.a8"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102990.2006.00743.x"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.41.4.479"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/61.3.282"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410300503"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010009\u20100485\u20104"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010008\u20100358\u20102"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010015\u20101509\u2010x"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s007020050096"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010022\u201002524\u20102"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010011\u20100871\u20106"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010020\u201000756\u20100"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)43176-1"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.1741"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024\u2010023\u201000653\u20100"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14500"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awae212"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14582"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.10.010"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010010\u20100707\u20109"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2015.08.008"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010024\u201005277\u20101"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2012.05.023"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M408127200"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaf016"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2015.09.011"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21843"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024\u2010022\u201000590\u20104"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aay1809"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006212"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478\u2010021\u201001250\u20102"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201019786\u20107"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022\u2010510X(99)00159\u20108"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.085805"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010021\u201002360\u2010w"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2021.07.017"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102990.1994.tb00951.x"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12978"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102202\u201015\u201074"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2024.106412"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1980\u201057642009DN30100002"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750\u20103639.1998.tb00161.x"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201032903\u2010y"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.70483","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.70483","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.70483","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:57:47Z","timestamp":1784303867000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.70483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":79,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/alz.70483"],"URL":"https:\/\/doi.org\/10.1002\/alz.70483","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2025.04.11.648343","asserted-by":"object"}]},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-04-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70483"}}