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The scope focuses on individuals with objective cognitive impairment, including those with mild cognitive impairment (MCI) or dementia, who are undergoing evaluation by providers trained and experienced in memory disorders, where AD is the suspected underlying etiology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>The panel conducted a systematic review to assess the diagnostic accuracy of BBMs in detecting AD pathology. The BBMs of interest included plasma phosphorylated\u2010tau (p\u2010tau) and amyloid\u2010beta (A\u03b2) tests measuring the following analytes: p\u2010tau217, ratio of p\u2010tau217 to non\u2010p\u2010tau217 \u00d7100 (%p\u2010tau17), p\u2010tau181, p\u2010tau231, and ratio of A\u03b242 to A\u03b240. The reference standard tests included cerebrospinal fluid (CSF) AD biomarkers, amyloid positron emission tomography (PET), or neuropathology. The panel applied the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach to assess the certainty of the evidence and the GRADE evidence\u2010to\u2010decision (EtD) Framework to develop its recommendations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RECOMMENDATIONS<\/jats:title>\n                    <jats:p>The key recommendations in this Clinical Practice Guideline (CPG) are: (1) BBM tests with \u226590% sensitivity and \u226575% specificity can be used as a triaging test and (2) BBM tests with \u226590% sensitivity and specificity can serve as a substitute for amyloid PET imaging or CSF AD biomarker testing in patients with cognitive impairment presenting to specialized care for memory disorders. The panel cautions users of this guideline that there is significant variability in diagnostic test accuracy and many commercially available BBM tests do not meet these thresholds, especially using a single cutoff. Additionally, these tests do not serve as a substitute for comprehensive clinical evaluation by a healthcare professional and should be used only as part of a full diagnostic workup of patients with cognitive impairment presenting to specialized care settings, and with careful consideration of pretest probability of AD pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS AND PRACTICAL IMPLICATIONS<\/jats:title>\n                    <jats:p>This CPG provides performance\u2010based, brand\u2010agnostic recommendations for the use of BBMs in the diagnostic workup of suspected AD within specialized care settings. By linking recommendations to a systematic review and associated living updates, and using a robust and transparent methodology, the guideline ensures scientific rigor, adaptability, and sustained relevance as evidence evolves. Clinicians are encouraged to stay informed about emerging paradigms\u2014such as biomarker combinations or ratios and multi\u2010threshold testing\u2014that may further refine the diagnostic accuracy of BBMs as the field evolves.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70535","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T18:01:05Z","timestamp":1753812065000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":213,"title":["Alzheimer's Association Clinical Practice Guideline on the use of blood\u2010based biomarkers in the diagnostic workup of suspected Alzheimer's disease within specialized care settings"],"prefix":"10.1002","volume":"21","author":[{"given":"Sebastian","family":"Palmqvist","sequence":"first","affiliation":[{"name":"Clinical Memory Research Unit Department of Clinical Sciences Malm\u00f6 Lund University Lund Sweden"},{"name":"Memory Clinic Sk\u00e5ne 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