{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T13:44:48Z","timestamp":1788270288229,"version":"build-2803163510"},"reference-count":61,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271977"],"award-info":[{"award-number":["82271977"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160327"],"award-info":[{"award-number":["82160327"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>Reduced blood perfusion has been observed in patients with Alzheimer's disease (AD), but the patterns of blood perfusion changes during AD progression remain insufficiently explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Quantitative transport mapping (QTM) is a novel biophysical modeling\u2010based method for quantifying blood perfusion velocity. In this study, we examined regional changes in perfusion velocity throughout AD progression by combining QTM velocity measurements with Granger causality analysis using cross\u2010sectional data, as a secondary and exploratory analysis following our previous QTM work, aiming to offer a comprehensive view of the QTM velocity patterns based on the arterial territories.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Reduced QTM velocity was observed in the middle cerebral artery (MCA)\u2013supplied regions for patients with mild cognitive impairment. The MCA\u2010supplied temporal lobe is a driving region of QTM velocity changes in other brain regions.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>The temporal lobe supplied by the MCA is the earliest brain region to exhibit changes in QTM velocity, indicating its potential as an early biomarker for AD diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Quantitative transport mapping (QTM) velocity was significantly reduced in the middle cerebral artery (MCA)\u2013supplied regions among patients with mild cognitive impairment, compared to cognitively normal individuals.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The temporal lobe supplied by the MCA is a driving region of QTM velocity changes in other brain regions.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The temporal lobe supplied by the MCA has great potential as an early biomarker for AD diagnosis.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.70540","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T03:14:56Z","timestamp":1753845296000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Decreased quantitative transport mapping velocity in the middle cerebral artery\u2013supplied temporal lobe in Alzheimer's disease"],"prefix":"10.1002","volume":"21","author":[{"given":"Yihao","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Radiology Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University)  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University)  Haikou 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