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Whether higher cfPWV amplifies the NfL\u2013cognition relationship remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Cognitively unimpaired older adults (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a0570) were assessed using composite cognitive scores from confirmatory factor analysis. cfPWV was dichotomized at the median. Plasma NfL was quantified on a Single Moleculte Array\u2010High Definition, model X (SIMOA\u2010HD X).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Higher NfL correlated with poorer performance across all cognitive domains (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05), and higher cfPWV was linked to worse episodic memory, working memory, and processing speed (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). NfL\u00d7 cfPWV interactions were significant for episodic (\u03b2\u00a0=\u00a00.289,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.048) and working memory (\u03b2\u00a0=\u00a00.287,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.025), with stronger NfL\u2013cognition associations in the higher cfPWV group (episodic memory: \u03b2\u00a0=\u00a0\u20100.324,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01; working memory: \u03b2\u00a0=\u00a0\u20100.343,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Greater cfPWV amplified the association between NfL\u2010related axonal degeneration and cognitive decline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>TRIAL REGISTRATION<\/jats:title>\n                    <jats:p>ClinicalTrials.gov: NCT02875301<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Neurofilament light (NfL) and carotid\u2010femoral pulse wave velocity (cfPWV) each correlate with poorer cognitive function in older adults.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Higher cfPWV exacerbates the link between NfL and cognitive deficits.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Arterial stiffness may worsen NfL\u2010related cognitive decline.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Findings reveal synergy between vascular and neurodegenerative aging markers.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Examining NfL or cfPWV alone may miss their synergistic effects on cognition.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70554","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T03:44:55Z","timestamp":1754624695000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Arterial stiffness moderates the link between NfL and cognition: The IGNITE 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