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Plasma tau levels decreased as Lewy body pathology progressed, even among individuals at the same tau Braak stage. All plasma biomarkers correlated with creatinine levels, as a marker of renal dysfunction, but this effect was mitigated when using the ratios phospho\/non\u2010phospho.<\/jats:p>\n <\/jats:sec>\n \n DISCUSSION<\/jats:title>\n Understanding how plasma tau biomarkers are influenced by co\u2010pathologies and comorbidities is crucial for their accurate implementation.<\/jats:p>\n <\/jats:sec>\n \n Highlights<\/jats:title>\n \n \n \n The plasma phosphorylated tau (p\u2010tau)217 ratio, followed by the p\u2010tau205 ratio and p\u2010tau217, were the best\u2010performing biomarkers for detecting neuropathologically confirmed Alzheimer's disease (AD).<\/jats:p>\n <\/jats:list-item>\n \n In high AD cases, p\u2010tau217 showed associations with neurofibrillary tangle (NFT) counts across all regions, while p\u2010tau205 was primarily linked to the frontal cortex, and non\u2010phosphorylated tau peptides were linked to the temporal cortex.<\/jats:p>\n <\/jats:list-item>\n \n We observed a decline in plasma tau levels as Lewy body pathology progressed, even among individuals at the same tau Braak stage.<\/jats:p>\n <\/jats:list-item>\n \n All plasma biomarkers correlated with creatinine levels, as a marker of renal dysfunction, but this effect was mitigated when using the ratios.<\/jats:p>\n <\/jats:list-item>\n \n Plasma p\u2010tau199 displayed a distinct behavior compared to other p\u2010tau species, showing no association with NFT counts in any brain region, but demonstrating significant correlations with brain volume and an effect on survival time.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/alz.70562","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T08:02:27Z","timestamp":1754985747000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Plasma tau biomarkers are distinctly associated with tau tangles and decreased with Lewy body pathology"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7684-6318","authenticated-orcid":false,"given":"Laia","family":"Montoliu\u2010Gaya","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience & Physiology The Sahlgrenska Academy at the University of Gothenburg M\u00f6lndal Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Valeriano\u2010Lorenzo","sequence":"additional","affiliation":[{"name":"Reina Sofia Foundation Alzheimer Center CIEN Foundation, ISCIII Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Ashton","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience & Physiology The Sahlgrenska Academy at the University of Gothenburg M\u00f6lndal Sweden"},{"name":"Institute of Psychiatry Psychology and 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