{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:20:58Z","timestamp":1787167258118,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,17]],"date-time":"2025-08-17T00:00:00Z","timestamp":1755388800000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371188"],"award-info":[{"award-number":["82371188"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3605400"],"award-info":[{"award-number":["2023YFC3605400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>\n                      The novel positron emission tomography (PET) tracer,\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010florzolotau, enables in vivo visualization of tau pathology.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      We evaluated the diagnostic performance of disease\u2010specific spatial patterns of\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010florzolotau PET imaging by visual read for tauopathies and its added value in diagnostic and therapeutic decision\u2010making in 1277 participants with cognitive complaints.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      The disease\u2010specific spatial patterns of\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010florzolotau PET imaging demonstrated high diagnostic accuracy in differentiating various tauopathies, with 96.0% for Alzheimer's disease, 94.4% for frontotemporal lobe degeneration, 93.7% for progressive supranuclear palsy, and 97.5% for corticobasal degeneration. Added to a standard diagnostic workup,\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010florzolotau PET reading led to diagnostic revisions for 247 participants (19.3%), increased diagnostic confidence from 68.6% to 81.3%, and resulted in medication changes for 284 participants (22.2%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>\n                      Our data advocate for the strategic implementation of\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010florzolotau PET in memory clinics, offering transformative potential for patient care and management.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>\n                            <jats:sup>18<\/jats:sup>\n                            F\u2010Florzolotau PET imaging presented disease\u2010specific spatial patterns for different tauopathies.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            The disease\u2010specific spatial patterns of\n                            <jats:sup>18<\/jats:sup>\n                            F\u2010florzolotau positron emission tomography (PET) imaging exhibited high diagnostic accuracy in differentiating various tauopathies.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            Integration of\n                            <jats:sup>18<\/jats:sup>\n                            F\u2010florzolotau PET imaging modality to a standard diagnostic workup significantly enhanced diagnostic confidence, enabled diagnostic revisions, and informed adjustments to treatment strategies.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70563","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T02:50:36Z","timestamp":1755485436000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Role of\n                    <sup>18<\/sup>\n                    F\u2010florzolotau PET in diagnostic and therapeutic decision\u2010making for cognitive impairment"],"prefix":"10.1002","volume":"21","author":[{"given":"Jun","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology and National Center for Neurological Disorders Huashan Hospital State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Shanghai Medical College Fudan University  Shanghai China"},{"name":"Department of Neurology and Center for Clinical Neuroscience Daping Hospital Third Military Medical University  Chongqing China"},{"name":"Chongqing Key Laboratory of Ageing and Brain Diseases  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi\u2010Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology and National Center for Neurological Disorders Huashan Hospital State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Shanghai Medical College Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu\u2010Fen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology and National Center for Neurological Disorders Huashan Hospital State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Shanghai Medical College Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong\u2010Ze","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology and National Center for Neurological Disorders Huashan Hospital State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Shanghai Medical College Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke\u2010Liang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology and National Center for Neurological Disorders Huashan Hospital State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Shanghai Medical College Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010Ying","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine &amp; PET Center Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010Wei","family":"Xin","sequence":"additional","affiliation":[{"name":"Department of Neurology and National Center for Neurological Disorders Huashan Hospital State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Shanghai Medical College Fudan University  Shanghai China"},{"name":"Department of Neurology Fujian Medical University Union Hospital Fujian Key Laboratory of Molecular Neurology and Institute of Neuroscience Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Yuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology and National Center for Neurological Disorders Huashan Hospital State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Shanghai Medical College Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Departments of Neurology Weifang People's Hospital  Weifang Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine &amp; PET Center Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Cheng","sequence":"additional","affiliation":[{"name":"Institute of Science and Technology for Brain\u2010Inspired Intelligence Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu\u2010Chen","family":"Yen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Center for Advanced Molecular Imaging and Translation Chang Gung Memorial Hospital Linkou Medical Center  Taiwan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude M.","family":"Wischik","sequence":"additional","affiliation":[{"name":"Institute of Medical Sciences University of Aberdeen  Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Neurology and National Center for Neurological Disorders Huashan Hospital State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Shanghai Medical College Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan\u2010Tao","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine &amp; PET Center Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian\u2010Hua","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology and National Center for Neurological Disorders Huashan Hospital State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Shanghai Medical College Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010Jiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology and Center for Clinical Neuroscience Daping Hospital Third Military Medical University  Chongqing China"},{"name":"Chongqing Key Laboratory of Ageing and Brain Diseases  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Tai","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Neurology and National Center for Neurological Disorders Huashan Hospital State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Shanghai Medical College Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13016"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-023-01321-7"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.09.042"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-022-00533-z"},{"issue":"3","key":"e_1_2_8_6_1","first-page":"781","article-title":"18F\u2010AV\u20101451 positron emission tomography in Alzheimer's disease and progressive supranuclear palsy","volume":"140","author":"Passamonti L","year":"2017","journal-title":"Brain"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-018-0342-8"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000003164"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28672"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14245"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.12917"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.0989"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-017-1740-8"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-022-06104-0"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-023-00447-0"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26987"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28263"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-023-02215-8"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.2000"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13728"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2023.1323"},{"issue":"5","key":"e_1_2_8_22_1","first-page":"61","article-title":"The differential diagnosis and treatment of atypical Parkinsonism","volume":"113","author":"Levin J","year":"2016","journal-title":"Dtsch Arztebl Int"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000201389"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12372"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13116"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.8392"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2023.5319"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-02869-z"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12356"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-024-00977-5"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.1858"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13859"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1148054"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.123.267273"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.70563","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T20:37:39Z","timestamp":1759955859000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.70563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":33,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1002\/alz.70563"],"URL":"https:\/\/doi.org\/10.1002\/alz.70563","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"2025-02-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70563"}}