{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:49:38Z","timestamp":1789584578850,"version":"build-2803163510"},"reference-count":70,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01\u2010AG37491"],"award-info":[{"award-number":["R01\u2010AG37491"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01\u2010NS112153"],"award-info":[{"award-number":["R01\u2010NS112153"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>\n                      Primary age\u2010related tauopathy (PART) is defined by neurofibrillary tangles (NFTs) with absent\u2010minimal amyloid beta (A\u03b2) plaques. Currently, definitive diagnosis of PART occurs with autopsy. This study investigated whether [\n                      <jats:sup>18<\/jats:sup>\n                      F]fluorodeoxyglucose positron emission tomography (FDG\u2010PET) could detect PART\u2010related metabolic changes and assessed the impact of common co\u2010pathologies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      We performed a retrospective cross\u2010sectional study of 88 individuals (mean age 85.6) with autopsy\u2010confirmed PART (Braak I to IV; Thal phases 0 to 2) who underwent\n                      <jats:italic>ante mortem<\/jats:italic>\n                      FDG\u2010PET. Visual ratings and standardized uptake value ratios (SUVRs) were analyzed in medial and lateral temporal lobes, inferior temporal pole, precuneus, and posterior cingulate regions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Medial temporal hypometabolism was observed in PART, in the presence of co\u2010pathologies. Argyrophilic grain disease and TAR DNA\u2010binding protein 43 were associated with greater hypometabolism (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01). Lewy body disease affected parietal regions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>FDG\u2010PET reveals that PART\u2010related hypometabolism occurs when co\u2010pathologies are present, but PART alone appears to have minimal effect on medial temporal lobe hypometabolism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>FDG\u2010PET hypometabolism worsens with Braak NFT stage.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>FDG\u2010PET detects mild lateral temporal lobe hypometabolism in PART alone.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>PART alone has a minimal effect on medial temporal lobe hypometabolism.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Medial temporal hypometabolism is worse in PART with TDP\u201043 and especially AGD.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The presence of LBD contributes to parietal hypometabolism on FGD\u2010PET in PART.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70568","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T08:05:15Z","timestamp":1755590715000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<sup>18<\/sup>\n                    F\u2010FDG PET in detection of primary age\u2010related tauopathy (PART) \u2013 Is there a role? Insights from an imaging\u2010pathology correlation study"],"prefix":"10.1002","volume":"21","author":[{"given":"Anna","family":"Lavrova","sequence":"first","affiliation":[{"name":"Department of Radiology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nha Trang Thu","family":"Pham","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia J.","family":"Vernon","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Graff\u2010Radford","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley 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