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A subset had cerebrospinal fluid \u03b1\u2010synuclein seed amplification assay (SAA) evaluation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Baseline mean SBRs were significant predictors of baseline and 24\u2010month MDS\u2010UPDRS\u2010III scores, although they did not predict meaningful worsening over time. SAA positivity was associated with lower SBRs;\n                      <jats:italic>Z<\/jats:italic>\n                      score cut\u2010off values are provided.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>\n                      In suspected DLB,\n                      <jats:sup>123<\/jats:sup>\n                      I\u2010ioflupane SPECT, at diagnosis, could be used to confirm underlying dopamine deficiency; it does not predict meaningful worsening of motor parkinsonism. More severe dopamine deficiency increases confidence in presence of synucleinopathy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>\n                            <jats:sup>123<\/jats:sup>\n                            I\u2010ioflupane single\u2010photon emission computed tomography (SPECT) can confirm underlying dopamine deficiency.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            Striatal binding ratio (SBR)\n                            <jats:italic>Z<\/jats:italic>\n                            scores predicted 24\u2010month Unified Parkinson's Disease Rating Scale\u2013Part III (UPDRS\u2010III) scores.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            SBR\n                            <jats:italic>Z<\/jats:italic>\n                            scores are not predictive of subsequent meaningful worsening of parkinsonism.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>More severe dopamine dysfunction on SPECT is associated with presence of seed amplification assay (SAA).<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            SBR\n                            <jats:italic>Z<\/jats:italic>\n                            score cut\u2010offs that indicate cerebrospinal fluid SAA positivity are provided.\n                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