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A subset (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a0312) had florbetapir positron emission tomography (2011\u20132014). BW was evaluated in association with dementia (Cox proportional hazards) and A\u03b2 (logistic regression), adjusted for demographics, apolipoprotein E \u03b54, and vascular risk. Effect modification by race was explored.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Neither low BW nor prematurity were associated with dementia. Dementia risk was elevated in Black (adjusted hazard ratio 1.95, 95% confidence interval 1.33, 2.86) but not White participants reporting high (versus medium) BW (\n                      <jats:italic>P\u2010<\/jats:italic>\n                      interaction\u00a0=\u00a00.001). BW was not associated with A\u03b2.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Low BW was not associated with dementia or A\u03b2. High BW was associated with dementia in Black participants only. Further research should evaluate the role of BW in dementia etiology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Low birth weight was not associated with an increased risk of incident dementia.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The association between birth weight and incident dementia was modified by race.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>High birth weight was associated with dementia in Black adults.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Odds of elevated standardized uptake value ratio was lower for those who were low birth weight.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70609","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T07:58:52Z","timestamp":1756799932000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Birth weight, incident dementia risk, and PET amyloid burden: The ARIC study"],"prefix":"10.1002","volume":"21","author":[{"given":"Olivia M.","family":"Emanuel","sequence":"first","affiliation":[{"name":"National Institute for Neurological Disorders and Stroke National Institutes of Health  Bethesda Maryland USA"},{"name":"Department of Clinical and Health Psychology University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Lee","sequence":"additional","affiliation":[{"name":"Minnesota Department of Health Community Health Division  St. Paul Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela L.","family":"Lutsey","sequence":"additional","affiliation":[{"name":"Division of Epidemiology &amp; Community Health University of Minnesota School of Public Health  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin J.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"The MIND Center University of Mississippi Medical Center  Jackson Mississippi USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9e C.","family":"Groechel","sequence":"additional","affiliation":[{"name":"National Institute for Neurological Disorders and Stroke National Institutes of Health  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Egle","sequence":"additional","affiliation":[{"name":"National Institute for Neurological Disorders and Stroke National Institutes of Health  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas H.","family":"Mosley","sequence":"additional","affiliation":[{"name":"The MIND Center University of Mississippi Medical Center  Jackson Mississippi USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea L. 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